Cpox Gene Summary [Mouse]
Enables coproporphyrinogen oxidase activity. A structural constituent of eye lens. Involved in heme A biosynthetic process; heme B biosynthetic process; and heme O biosynthetic process. Acts upstream of or within heme biosynthetic process. Located in membrane and mitochondrion. Is active in mitochondrial intermembrane space. Is expressed in embryo; liver; and yolk sac. Used to study hereditary coproporphyria. Human ortholog(s) of this gene implicated in hereditary coproporphyria and liver disease. Orthologous to human CPOX (coproporphyrinogen oxidase). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cpox |
| Official Name | coproporphyrinogen oxidase [Source:MGI Symbol;Acc:MGI:104841] |
| Ensembl ID | ENSMUSG00000022742 |
| Bio databases IDs | |
| Aliases | coproporphyrinogen oxidase |
| Synonyms | cac, Coprogen oxidase, coproporphyrinogen oxidase, COX, CPO, CPX, HARPO, HCP, HEM6, M100835, nct, Rgsc835 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cpox often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- structural constituent of eye lens
- coproporphyrinogen oxidase
- protein homodimerization
- Na+/K+-exchanging ATPase
- enzyme
- identical protein binding
- Coproporphyrinogen III oxidase
Pathways
Biological processes and signaling networks where the Cpox gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hereditary disorder
- coproporphyria
- harderoporphyria
- organismal death
- dominant hereditary coproporphyria
- digenic coproporphyria
regulates
- heme
- Na+
- K+
- protoporphyrinogen
- heme a
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Mitochondria
- cytosol
- mitochondrial intermembrane space
- mitochondrial inner membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cpox gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- heme O biosynthetic process
- heme biosynthetic process
- heme a biosynthetic process
- protoporphyrinogen IX biosynthetic process
- heme b biosynthetic process
Cellular Component
Where in the cell the gene product is active
- mitochondrial intermembrane space
- cytoplasm
- mitochondrion
- membrane
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein homodimerization activity
- coproporphyrinogen oxidase activity
- structural constituent of eye lens