Tmprss15 Gene Summary [Mouse]
This gene encodes an enzyme that proteolytically activates the pancreatic proenzyme trypsinogen, converting it into trypsin. The encoded protein is cleaved into two chains that form a heterodimer linked by a disulfide bond. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2013]
Details
| Type | Protein Coding |
| Official Symbol | Tmprss15 |
| Official Name | transmembrane protease, serine 15 [Source:MGI Symbol;Acc:MGI:1197523] |
| Ensembl ID | ENSMUSG00000022857 |
| Bio databases IDs | |
| Aliases | transmembrane protease, serine 15 |
| Synonyms | enterokinase, ENTEROPEPTIDASE, ENTK, proenterokinase, PRSS7, transmembrane protease, serine 15, transmembrane serine protease 15 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tmprss15 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Scavenger receptor cysteine-rich domain
- Trypsin-like serine protease
- Tryp_SPc
- enteropeptidase
- peptidase
- SEA domain
- protein binding
- Scavenger receptor Cys-rich
- Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
- trypsin
- CUB
- LDLa
- MAM domain, meprin/A5/mu
Pathways
Biological processes and signaling networks where the Tmprss15 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cellular membrane
- brush border
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tmprss15 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- proteolysis
Cellular Component
Where in the cell the gene product is active
- brush border
- membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- serine-type endopeptidase activity