Hrg Gene Summary [Mouse]
Enables serine-type endopeptidase inhibitor activity. Involved in several processes, including defense response to other organism; negative regulation of blood vessel endothelial cell migration; and positive regulation of blood vessel remodeling. Acts upstream of or within negative regulation of fibrinolysis. Located in collagen-containing extracellular matrix. Human ortholog(s) of this gene implicated in thrombophilia due to HRG deficiency and thrombosis. Orthologous to human HRG (histidine rich glycoprotein). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hrg |
| Official Name | histidine-rich glycoprotein [Source:MGI Symbol;Acc:MGI:2146636] |
| Ensembl ID | ENSMUSG00000022877 |
| Bio databases IDs | |
| Aliases | histidine-rich glycoprotein |
| Synonyms | D16jh2, D18020, Histidine-rich glycoprotein, HPRG, HRG1, HRG beta-1, HRGP, HRG β-1, THPH11 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Hrg often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- CY
- cystatin-like domain
- histidine rich acidic repeat
- serine protease inhibitor activity
- metal ion binding
- protein binding
- receptor binding
- heme binding
- Histidine proline rich domain
- immunoglobulin binding
- binding protein
- cytoplasmic domain
- zinc ion binding
- heparin binding
Pathways
Biological processes and signaling networks where the Hrg gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hypoxia
- liver cancer
- digestive system cancer
- abdominal cancer
- cancer
- epithelial cancer
- epithelial neoplasia
- hepatocellular carcinoma
- neoplasia
- COVID-19
role in cell
- expression in
- apoptosis
- proliferation
- killing
- growth
- adhesion
- migration
- invasion by
- cellular infiltration by
- number
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cell surface
- Plasma Membrane
- alpha granules
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Hrg gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of angiogenesis
- regulation of blood coagulation
- negative regulation of cell proliferation
- fibrinolysis
- negative regulation of vascular endothelial growth factor signaling pathway
- chemotaxis
- regulation of peptidyl-tyrosine phosphorylation
- angiogenesis
- negative regulation of cell growth
- negative regulation of endothelial cell chemotaxis
- negative regulation of endopeptidase activity
- positive regulation of immune response to tumor cell
- defense response to fungus
- platelet activation
- negative regulation of blood vessel endothelial cell migration
- negative regulation of lamellipodium assembly
- negative regulation of fibrinolysis
- negative regulation of cell adhesion
- regulation of protein complex assembly
- negative regulation of cell adhesion mediated by integrin
- positive regulation of focal adhesion assembly
- regulation of actin cytoskeleton organization
- positive regulation of blood vessel remodeling
- positive regulation of apoptotic process
- regulation of gene expression
- cytolysis by host of symbiont cells
- regulation of platelet activation
Cellular Component
Where in the cell the gene product is active
- platelet alpha granule lumen
- extracellular vesicular exosome
- blood microparticle
- extracellular region
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- serine-type endopeptidase inhibitor activity
- zinc ion binding
- protein binding
- cysteine-type endopeptidase inhibitor activity
- metal ion binding
- heparan sulfate proteoglycan binding
- heparin binding
- immunoglobulin binding
- receptor binding
- heme binding