Cd83 Gene Summary [Mouse]
Acts upstream of or within positive regulation of CD4-positive, alpha-beta T cell differentiation and regulation of cytokine production. Located in external side of plasma membrane. Is expressed in alimentary system; genitourinary system; hemolymphoid system gland; nervous system; and otocyst. Orthologous to human CD83 (CD83 molecule). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cd83 |
| Official Name | CD83 antigen [Source:MGI Symbol;Acc:MGI:1328316] |
| Ensembl ID | ENSMUSG00000015396 |
| Bio databases IDs | |
| Aliases | CD83 antigen |
| Synonyms | BL11, CD83 ANTIGEN, CD83 molecule, HB15 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cd83 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- immunoglobulin domain
- Immunoglobulin like
- Immunoglobulin I-set domain
- protein binding
- transmembrane receptor
- Immunoglobulin V-set domain
Pathways
Biological processes and signaling networks where the Cd83 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- peripheral arterial disease
- diabetic nephropathy
- cervical cancer
- epileptic seizure
- multiple system atrophy
- lepromatous leprosy
- Graves disease
- polyglandular autoimmune syndrome type 1
- Devic syndrome
- Waldenström macroglobulinemia
role in cell
- proliferation
- expression in
- production in
- formation
- binding
- quantity
- maturation
- activation
- response
- upregulation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cell surface
- cellular membrane
- Golgi Apparatus
- plasma membrane extracellular face
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cd83 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of interleukin-4 production
- positive regulation of CD4-positive, alpha-beta T cell differentiation
- signal transduction
- humoral immune response
- CD4-positive, alpha-beta T cell differentiation
- response to organic cyclic compound
- positive regulation of interleukin-10 production
- defense response
- positive regulation of interleukin-2 production
Cellular Component
Where in the cell the gene product is active
- external side of plasma membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding