Faim2 Gene Summary [Mouse]
Predicted to enable calcium channel activity. Involved in cerebellar Purkinje cell differentiation; cerebellar granular layer development; and regulation of neuron apoptotic process. Acts upstream of or within negative regulation of apoptotic signaling pathway; negative regulation of neuron apoptotic process; and response to ischemia. Located in Golgi apparatus; endoplasmic reticulum; and membrane raft. Is expressed in several structures, including alimentary system; brain; genitourinary system; immune system; and white fat. Orthologous to human FAIM2 (Fas apoptotic inhibitory molecule 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Faim2 |
| Official Name | Fas apoptotic inhibitory molecule 2 [Source:MGI Symbol;Acc:MGI:1919643] |
| Ensembl ID | ENSMUSG00000023011 |
| Bio databases IDs | |
| Aliases | Fas apoptotic inhibitory molecule 2 |
| Synonyms | 2900002L20Rik, AI854036, Fas apoptotic inhibitory molecule 2, LFG, LFG2, LOC100909872, LOC102551901, NGP35, NMP25, NMP35, TMBIM2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Faim2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Inhibitor of apoptosis-promoting Bax1
- BAX inhibitor (BI)-1/YccA-like protein family
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- overnutrition
- obesity
- diabetes mellitus
- metastasis
- diabetic nephropathy
- non-small cell lung cancer
- organismal death
- morbid obesity
- gout
role in cell
- cell viability
- expression in
- cell death
- differentiation
- survival
- proliferation
- invasion by
- apoptosis
- quantity
- density
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- Cytoplasm
- perinuclear region
- cellular membrane
- vesicles
- Golgi Apparatus
- Endoplasmic Reticulum
- postsynaptic membrane
- Golgi membrane
- membrane rafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Faim2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cerebellar Purkinje cell layer development
- cerebellar granular layer development
- response to ischemia
- cerebellar Purkinje cell differentiation
- cerebellum development
- negative regulation of apoptotic process
- apoptotic signaling pathway
- regulation of neuron apoptotic process
- neuron apoptotic process
- negative regulation of apoptotic signaling pathway
- negative regulation of neuron apoptotic process
Cellular Component
Where in the cell the gene product is active
- postsynaptic membrane
- membrane
- membrane raft
- Golgi apparatus
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- protein binding