Krt6b Gene Summary [Mouse]
Predicted to be a structural constituent of skin epidermis. Acts upstream of or within intermediate filament organization; keratinization; and morphogenesis of an epithelium. Predicted to be active in keratin filament. Is expressed in oral epithelium; skin; and tongue. Human ortholog(s) of this gene implicated in focal or diffuse nonepidermolytic palmoplantar keratoderma and pachyonychia congenita. Orthologous to several human genes including KRT6B (keratin 6B). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Krt6b |
| Official Name | keratin 6B [Source:MGI Symbol;Acc:MGI:1333768] |
| Ensembl ID | ENSMUSG00000023041 |
| Bio databases IDs | |
| Aliases | keratin 6B |
| Synonyms | CK-6B, Cytokeratin 6B, K6B, K6beta, keratin 6B, Krt2-6b, KRTL1, mK6[b], PC2, PC4 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Krt6b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- structural constituent of cytoskeleton
- protein binding
- Intermediate filament protein
- Keratin type II head
Pathways
Biological processes and signaling networks where the Krt6b gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- lung cancer
- epithelial cancer
- plaque psoriasis
- diabetic nephropathy
- growth failure
- pachyonychia congenita 4
- adenocarcinoma
- cholesteatoma
- lung squamous cell carcinoma
- squamous cell lung cancer
role in cell
- damage
- migration
- organization
- rupture
- epithelialization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Krt6b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ectoderm development
- keratinization
- intermediate filament organization
Cellular Component
Where in the cell the gene product is active
- keratin filament
- extracellular vesicular exosome
- cytosol
Molecular Function
What the gene product does at the molecular level
- structural constituent of epidermis
- protein binding
- structural constituent of cytoskeleton