Celsr3 Gene Summary [Mouse]
Predicted to enable G protein-coupled receptor activity and calcium ion binding activity. Involved in Wnt signaling pathway, planar cell polarity pathway; dopaminergic neuron axon guidance; and serotonergic neuron axon guidance. Acts upstream of or within several processes, including cilium assembly; generation of neurons; and regulation of protein phosphorylation. Is active in glutamatergic synapse; postsynaptic density membrane; and presynaptic active zone membrane. Is expressed in several structures, including central nervous system; embryo ectoderm; epiblast; peripheral nervous system; and retina. Orthologous to human CELSR3 (cadherin EGF LAG seven-pass G-type receptor 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Celsr3 |
| Official Name | cadherin, EGF LAG seven-pass G-type receptor 3 [Source:MGI Symbol;Acc:MGI:1858236] |
| Ensembl ID | ENSMUSG00000023473 |
| Bio databases IDs | |
| Aliases | cadherin, EGF LAG seven-pass G-type receptor 3 |
| Synonyms | ADGRC3, cadherin EGF LAG seven-pass G-type receptor 3, cadherin, EGF LAG seven-pass G-type receptor 3, CDHF11, EGFL1, flamingo, FMI1, HFMI1, MEGF2, mKIAA0812, RESDA1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Celsr3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- Hormone receptor domain
- 7 transmembrane receptor (Secretin family)
- LamG
- GPCR-Autoproteolysis INducing (GAIN) domain
- Human growth factor-like EGF
- Keratin, high sulfur B2 protein
- protein binding
- seven-transmembrane G protein-coupled receptor superfamily
- EGF_CA
- Laminin-type epidermal growth factor-like domai
- Cadherin repeat-like domain
- EGF domain
- GPCR proteolysis site, GPS, motif
- laminin G domain
Pathways
Biological processes and signaling networks where the Celsr3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Crohn disease
- cancer
- respiratory failure
- colorectal cancer
- inflammatory bowel disease
- neuroendocrine prostate cancer
- X-linked immunodeficiency with magnesium defect, Epstein-Barr virus infection and neoplasia
- cyanosis
- nonsyndromic renal hypodysplasia 1
- atelectasis
role in cell
- differentiation
- migration
- quantity
- migration by
- assembly
- patterning
- patterning in
- fasciculation
- guidance
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- glutaminergic synapse
- cell surface
- cellular membrane
- presynaptic membrane
- synaptic membrane
- growth cone
- axons
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Celsr3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- G-protein coupled receptor signaling pathway
- Wnt receptor signaling pathway, planar cell polarity pathway
- homophilic cell adhesion
Cellular Component
Where in the cell the gene product is active
- membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- G-protein coupled receptor activity
- protein binding
- calcium ion binding