Swap70 Gene Summary [Mouse]
Enables ATP binding activity and DNA binding activity. Involved in several processes, including negative regulation of cell-cell adhesion mediated by integrin; positive regulation of mast cell chemotaxis; and regulation of actin filament organization. Acts upstream of or within isotype switching. Located in nucleus. Is expressed in cerebral cortex ventricular layer and cortical plate. Orthologous to human SWAP70 (switching B cell complex subunit SWAP70). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Swap70 |
| Official Name | SWA-70 protein [Source:MGI Symbol;Acc:MGI:1298390] |
| Ensembl ID | ENSMUSG00000031015 |
| Bio databases IDs | |
| Aliases | SWA-70 protein |
| Synonyms | AV235546, HSPC321, KIAA0640, SWA-70 protein, switching B-cell complex subunit SWAP70 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Swap70 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Cortexillin I, coiled coil
- EF-Hand
- Tropomyosin like
- Ezrin/radixin/moesin, alpha-helical domain
- PspA/IM30 family
- ATP binding
- protein binding
- Pleckstrin homology-like domain
- DNA binding
- MAP7 (E-MAP-115) family
- guanyl-nucleotide exchange factor
- Family with sequence similarity 184, A and B
- PH domain
- Dbl homology domain
- Domain of unknown function (DUF4200)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cardiovascular disorder
- hypertension
- ischemic stroke
- rheumatoid arthritis
- major depression
- coronary artery disease
- myocardial infarction
- hemolysis
- mature B-cell neoplasia
- splenic marginal zone B-cell lymphoma
role in cell
- expression in
- proliferation
- activation in
- phosphorylation in
- quantity
- apoptosis
- binding in
- growth
- degranulation
- upregulation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane fraction
- postsynaptic region
- podosomes
- actin cytoskeleton
- Nucleus
- Plasma Membrane
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Swap70 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of actin filament depolymerization
- regulation of small GTPase mediated signal transduction
- regulation of protein localization
- positive regulation of actin filament bundle assembly
- positive regulation of mast cell chemotaxis
- actin filament bundle assembly
- negative regulation of cell-cell adhesion mediated by integrin
- isotype switching
- elevation of cytosolic calcium ion concentration
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- actin cytoskeleton
- cytosol
- plasma membrane
- lamellipodium
Molecular Function
What the gene product does at the molecular level
- ATP binding
- DNA binding
- protein binding
- cadherin binding
- calcium ion binding
- guanyl-nucleotide exchange factor activity