Tnfrsf12a Gene Summary [Mouse]
Involved in regulation of angiogenesis. Acts upstream of or within extrinsic apoptotic signaling pathway; positive regulation of axon extension; and substrate-dependent cell migration, cell attachment to substrate. Located in cell surface; plasma membrane; and ruffle. Is expressed in several structures, including adrenal medulla; alimentary system; genitourinary system; heart; and limb long bone. Orthologous to human TNFRSF12A (TNF receptor superfamily member 12A). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tnfrsf12a |
| Official Name | tumor necrosis factor receptor superfamily, member 12a [Source:MGI Symbol;Acc:MGI:1351484] |
| Ensembl ID | ENSMUSG00000023905 |
| Bio databases IDs | |
| Aliases | tumor necrosis factor receptor superfamily, member 12a |
| Synonyms | CD266, FN14, HPIP, TNF receptor superfamily member 12A, TNFRS12A, tumor necrosis factor receptor superfamily, member 12a, tumour necrosis factor receptor superfamily, member 12a, TWEAK-R |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tnfrsf12a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- TRAF binding domain
- ligand-binding domain
- ectodomain
- extracellular ligand binding domain
- protein binding
- Tumor necrosis factor receptor superfamily (TNFRSF)
- transmembrane receptor
Pathways
Biological processes and signaling networks where the Tnfrsf12a gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- squamous cell cancer
- autosomal dominant polycystic kidney disease
- stroke
- androgenic alopecia
- dextran sodium sulfate-induced colitis
- papilloma
- papillomatosis
- metastasis
- squamous-cell carcinoma
role in cell
- production in
- cell death
- apoptosis
- activation in
- formation
- proliferation
- growth
- quantity
- differentiation
- outgrowth
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- ruffle
- Cytoplasm
- cell surface
- cell periphery
- cellular membrane
- Nucleus
- membrane ruffles
- filopodia
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tnfrsf12a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of wound healing
- angiogenesis
- positive regulation of apoptotic process
- apoptotic process
- cell differentiation
- cell adhesion
- positive regulation of extrinsic apoptotic signaling pathway
Cellular Component
Where in the cell the gene product is active
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding