TNFRSF12A Gene Summary [Human]
Involved in positive regulation of extrinsic apoptotic signaling pathway and regulation of wound healing. Predicted to be located in cell surface and ruffle. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | TNFRSF12A |
| Official Name | TNF receptor superfamily member 12A [Source:HGNC Symbol;Acc:HGNC:18152] |
| Ensembl ID | ENSG00000006327 |
| Bio databases IDs | |
| Aliases | TNF receptor superfamily member 12A |
| Synonyms | CD266, FN14, HPIP, TNF receptor superfamily member 12A, TNFRS12A, tumor necrosis factor receptor superfamily, member 12a, tumour necrosis factor receptor superfamily, member 12a, TWEAK-R |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TNFRSF12A often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- TRAF binding domain
- ligand-binding domain
- ectodomain
- extracellular ligand binding domain
- protein binding
- Tumor necrosis factor receptor superfamily (TNFRSF)
- transmembrane receptor
Pathways
Biological processes and signaling networks where the TNFRSF12A gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- squamous cell cancer
- autosomal dominant polycystic kidney disease
- stroke
- androgenic alopecia
- dextran sodium sulfate-induced colitis
- papilloma
- papillomatosis
- metastasis
- squamous-cell carcinoma
role in cell
- production in
- cell death
- apoptosis
- activation in
- formation
- proliferation
- growth
- quantity
- differentiation
- outgrowth
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- ruffle
- Cytoplasm
- cell surface
- cell periphery
- cellular membrane
- Nucleus
- membrane ruffles
- filopodia
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TNFRSF12A gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of wound healing
- angiogenesis
- positive regulation of apoptotic process
- apoptotic process
- cell differentiation
- cell adhesion
- positive regulation of extrinsic apoptotic signaling pathway
Cellular Component
Where in the cell the gene product is active
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding