Pkmyt1 Gene Summary [Mouse]
Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in meiotic cell cycle; negative regulation of G2/M transition of mitotic cell cycle; and negative regulation of G2/MI transition of meiotic cell cycle. Located in cytoplasm and nucleus. Is expressed in several structures, including brain ventricular layer; early embryo; oocyte; retina; and thymus primordium. Orthologous to human PKMYT1 (protein kinase, membrane associated tyrosine/threonine 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pkmyt1 |
| Official Name | protein kinase, membrane associated tyrosine/threonine 1 [Source:MGI Symbol;Acc:MGI:2137630] |
| Ensembl ID | ENSMUSG00000023908 |
| Bio databases IDs | |
| Aliases | protein kinase, membrane associated tyrosine/threonine 1 |
| Synonyms | 6230424P17, MYT1, PPP1R126, protein kinase, membrane associated tyrosine/threonine 1, RGD1305434 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pkmyt1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- protein kinase
- Protein Kinases, catalytic domain
- Protein tyrosine and serine/threonine kinase
- transmembrane domain
- protein binding
- Protein kinase domain
- Tyrosine kinase, catalytic domain
Pathways
Biological processes and signaling networks where the Pkmyt1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metabolic syndrome X
- lung squamous cell carcinoma
- prostate cancer
- epithelial cancer
- lung adenocarcinoma
- lung adenocarcinoma formation
- breast carcinoma
- hepatocellular carcinoma
- liver cancer
- thyroid carcinoma
role in cell
- apoptosis
- migration
- cell death
- invasion by
- activation in
- growth
- mitosis
- G2/M phase transition
- mitotic entry
- mitotic exit
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Nucleus
- Golgi Apparatus
- Endoplasmic Reticulum
- cytosol
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pkmyt1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- meiotic cell cycle
- G2/M transition of mitotic cell cycle
- regulation of mitosis
- protein phosphorylation
- negative regulation of G2/M transition of mitotic cell cycle
- mitotic cell cycle
- regulation of cyclin-dependent protein kinase activity
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- nucleus
- cytoplasm
- membrane
- cytosol
- Golgi membrane
- Golgi apparatus
- endoplasmic reticulum
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- metal ion binding
- protein kinase activity
- protein serine/threonine kinase activity
- kinase activity