Gtpbp2 Gene Summary [Mouse]
Predicted to enable several functions, including GTP binding activity; alpha-aminoacyl-tRNA binding activity; and translation elongation factor activity. Acts upstream of or within nuclear-transcribed mRNA catabolic process, no-go decay and rescue of stalled ribosome. Is expressed in central nervous system and eye. Orthologous to human GTPBP2 (GTP binding protein 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | Gtpbp2 |
| Official Name | GTP binding protein 2 [Source:MGI Symbol;Acc:MGI:1860138] |
| Ensembl ID | ENSMUSG00000023952 |
| Bio databases IDs | |
| Aliases | GTP binding protein 2 |
| Synonyms | GTP binding protein 2, JABELS, nmf205 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gtpbp2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- GTP binding
- Domain III of Elongation factor (EF) Tu (EF-TU) and related proteins
- Domain II of Elongation factor Tu (EF-Tu)-like proteins
- enzyme
- protein binding
- Elongation factor Tu GTP binding domain
- Elongation factor Tu domain 2
- identical protein binding
- P-loop containing Nucleoside Triphosphate Hydrolases
- RNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- alpha granules
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Gtpbp2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- translational elongation
Cellular Component
Where in the cell the gene product is active
- platelet alpha granule lumen
- extracellular region
Molecular Function
What the gene product does at the molecular level
- GTP binding
- identical protein binding
- protein binding
- translation elongation factor activity
- GTPase activity