Tff2 Gene Summary [Mouse]
Enables CXCR4 chemokine receptor binding activity. Acts upstream of or within several processes, including negative regulation of gastric acid secretion; negative regulation of macrophage activation; and positive regulation of ERK1 and ERK2 cascade. Located in extracellular space. Is expressed in several structures, including alimentary system; genitourinary system; liver; skeleton; and thymus. Orthologous to human TFF2 (trefoil factor 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tff2 |
| Official Name | trefoil factor 2 (spasmolytic protein 1) [Source:MGI Symbol;Acc:MGI:1306805] |
| Ensembl ID | ENSMUSG00000024028 |
| Bio databases IDs | |
| Aliases | trefoil factor 2 (spasmolytic protein 1) |
| Synonyms | mSP, SML1, SP, spasmolytic protein 1, trefoil factor 2, trefoil factor 2 (spasmolytic protein 1) |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tff2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- Trefoil
- CXCR chemokine receptor binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- carbon tetrachloride-induced liver fibrosis
- neoplasia
- cholangiocarcinoma
- cholangiocarcinoma cancer
- ulceration
- gastric adenocarcinoma
- gastric epithelial cancer
role in cell
- proliferation
- invasion
- activation
- migration
- quantity
- phosphorylation in
- cell movement
- chemotaxis
- scattering
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tff2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- chemokine-mediated signaling pathway
- maintenance of gastrointestinal epithelium
- negative regulation of gastric acid secretion
Cellular Component
Where in the cell the gene product is active
- extracellular space
Molecular Function
What the gene product does at the molecular level
- CXCR4 chemokine receptor binding
- protein binding