Slc27a3 Gene Summary [Mouse]
Enables fatty-acyl-CoA synthase activity. Predicted to be involved in fatty acid transport and long-chain fatty acid metabolic process. Predicted to act upstream of or within acyl-CoA metabolic process. Located in mitochondrion. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; sensory organ; and skeleton. Orthologous to human SLC27A3 (solute carrier family 27 member 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Slc27a3 |
| Official Name | solute carrier family 27 (fatty acid transporter), member 3 [Source:MGI Symbol;Acc:MGI:1347358] |
| Ensembl ID | ENSMUSG00000027932 |
| Bio databases IDs | |
| Aliases | solute carrier family 27 (fatty acid transporter), member 3 |
| Synonyms | ACSVL3, FATP-3, solute carrier family 27 (fatty acid transporter), member 3, solute carrier family 27 member 3, VLCS-3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Slc27a3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- long-chain-fatty-acid-CoA ligase
- fatty-acid ligase
- AMP-binding enzyme
- acid-thiol ligase
- CoA-ligase
- Adenylate forming domain, Class I superfamily
- O-succinylbenzoate-CoA ligase
- AMP-binding enzyme C-terminal domain
- amino acid adenylation domain
- transporter
- fatty-acyl-CoA synthase
Pathways
Biological processes and signaling networks where the Slc27a3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- mitochondrial fraction
- cellular membrane
- Plasma Membrane
- Endoplasmic Reticulum
- Mitochondria
- mitochondrial membrane
- mitochondrial matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Slc27a3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- long-chain fatty acid metabolic process
- fatty acid transport
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- mitochondrial membrane
- mitochondrion
- membrane
- endoplasmic reticulum
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- very long-chain fatty acid-CoA ligase activity
- ATP binding
- arachidonate-CoA ligase activity
- long-chain fatty acid-CoA ligase activity