Lrig3 Gene Summary [Mouse]
Acts upstream of or within otolith morphogenesis. Predicted to be located in cytoplasmic vesicle membrane and plasma membrane. Is expressed in several structures, including branchial arch; embryo mesenchyme; nervous system; pancreas tip epithelium; and sensory organ. Orthologous to human LRIG3 (leucine rich repeats and immunoglobulin like domains 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Lrig3 |
| Official Name | leucine-rich repeats and immunoglobulin-like domains 3 [Source:MGI Symbol;Acc:MGI:2443955] |
| Ensembl ID | ENSMUSG00000020105 |
| Bio databases IDs | |
| Aliases | leucine-rich repeats and immunoglobulin-like domains 3 |
| Synonyms | 9030421L11RIK, 9130004I02Rik, 9430095K15Rik, leucine-rich repeats and immunoglobulin-like domains 3, LIG3, mKIAA3016, RGD1561255 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Lrig3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein phosphatase 1 regulatory subunit 42
- immunoglobulin domain
- Immunoglobulin like
- Immunoglobulin I-set domain
- Leucine rich repeat
- Leucine rich repeat C-terminal domain
- Leucine rich repeat N-terminal domain
- BspA type Leucine rich repeat region (6 copies)
- protein binding
- Leucine Rich repeats (2 copies)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- survival
- osteoarthritis
- psoriasis
- hip osteoarthritis
role in cell
- expression in
- phosphorylation in
- stabilization in
- M2 polarization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Lrig3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- otolith morphogenesis
Cellular Component
Where in the cell the gene product is active
- extracellular space
- cytoplasmic vesicle membrane
- extracellular matrix
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding