Mapk8ip1 Gene Summary [Mouse]
Enables kinesin binding activity and protein kinase binding activity. Involved in positive regulation of JNK cascade and regulation of CD8-positive, alpha-beta T cell proliferation. Acts upstream of or within several processes, including JUN phosphorylation; negative regulation of intrinsic apoptotic signaling pathway; and regulation of DNA-templated transcription. Located in several cellular components, including dendrite; dentate gyrus mossy fiber; and neuronal cell body. Is expressed in several structures, including early conceptus; genitourinary system; musculature; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human MAPK8IP1 (mitogen-activated protein kinase 8 interacting protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mapk8ip1 |
| Official Name | mitogen-activated protein kinase 8 interacting protein 1 [Source:MGI Symbol;Acc:MGI:1309464] |
| Ensembl ID | ENSMUSG00000027223 |
| Bio databases IDs | |
| Aliases | mitogen-activated protein kinase 8 interacting protein 1 |
| Synonyms | IB1, Islet brain 1, JIP-1, JNK-INTERACTING protein 1, Mapk8ip, mitogen-activated protein kinase 8 interacting protein 1, mjip-2a, PRKM8IP, Skip |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mapk8ip1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein interaction domain
- protein kinase binding
- MKK7 binding domain
- MAPK binding site
- MLK binding domain
- Pst domain
- protein kinase inhibitor activity
- JUN kinase binding
- protein binding
- phosphotyrosine binding domain
- Pleckstrin homology-like domain
- Jnk-binding domain
- identical protein binding
- kinesin binding
- Src Homology 3 domain superfamily
- MAP-kinase scaffold protein
- kinesin1 binding domain
- hinge domain
Pathways
Biological processes and signaling networks where the Mapk8ip1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- colorectal carcinoma
- colorectal carcinomagenesis
- non-insulin-dependent diabetes mellitus
- hypoglycemia
- Alzheimer disease
- insulin resistance
- Waldenström macroglobulinemia
- growth failure
- lung adenocarcinoma
role in cell
- cell death
- expression in
- activation in
- apoptosis
- proliferation
- survival
- transactivation in
- phosphorylation in
- destruction
- binding in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- plasma membrane fraction
- nuclear fraction
- peripheral membrane fraction
- membrane fraction
- axon component
- cell surface
- perinuclear region
- cellular membrane
- Nucleus
- Plasma Membrane
- Endoplasmic Reticulum
- Mitochondria
- cytosol
- plasma membrane projections
- sperm tail
- growth cone
- neurites
- synapse
- perikaryon
- axons
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mapk8ip1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- vesicle-mediated transport
- negative regulation of JUN kinase activity
- positive regulation of JNK cascade
- regulation of transcription, DNA-dependent
- JNK cascade
- negative regulation of intrinsic apoptotic signaling pathway
- regulation of CD8-positive, alpha-beta T cell proliferation
- regulation of JNK cascade
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- dendrite
- nucleus
- mitochondrial membrane
- perinuclear region of cytoplasm
- cytoplasm
- cytosol
- dentate gyrus mossy fiber
- neuronal cell body
- synapse
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- kinesin binding
- JUN kinase binding
- MAP-kinase scaffold activity
- protein kinase inhibitor activity