Mllt1 Gene Summary [Mouse]
Predicted to enable chromatin binding activity and lysine-acetylated histone binding activity. Acts upstream of or within negative regulation of protein kinase activity. Located in nucleus. Is expressed in several structures, including brain; branchial arch; limb; maxillary process; and sensory organ. Orthologous to human MLLT1 (MLLT1 super elongation complex subunit). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mllt1 |
| Official Name | myeloid/lymphoid or mixed-lineage leukemia; translocated to, 1 [Source:MGI Symbol;Acc:MGI:1927238] |
| Ensembl ID | ENSMUSG00000024212 |
| Bio databases IDs | |
| Aliases | myeloid/lymphoid or mixed-lineage leukemia; translocated to, 1 |
| Synonyms | BAM11, ENL, LOC56930, LTG19, MLLT1 super elongation complex subunit, MLLT1, super elongation complex subunit, myeloid/lymphoid or mixed-lineage leukaemia; translocated to, 1, myeloid/lymphoid or mixed-lineage leukemia; translocated to, 1, YEATS1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mllt1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- YEATS domain
- YEATS domain family, chromatin reader proteins
- transcription regulator
- ANC1 homology domain (AHD)
- transcription activation domain
- helical domain
- protein binding
- YEATS family
- polyproline motif
- prokaryotic YEATS domain
- serine-proline rich domain
- hydrophobic domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- obesity
- Wilms tumor
- Wilms tumorigenesis
- leukemic transformation
- neoplastic cell transformation
regulated by
- AFF1
- cocaine
role in cell
- expression in
- growth
- maturation
- proliferation
- differentiation
- transformation
- colony formation
- phagocytosis by
- immortalization
- phagocytosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- fibrillar center
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mllt1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of transcription, DNA-dependent
Cellular Component
Where in the cell the gene product is active
- transcription elongation factor complex
- cytosol
- fibrillar center
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- histone acetyl-lysine binding
- chromatin binding