Hoxa11 Gene Summary [Mouse]
This gene is located in a cluster of developmentally and temporally regulated genes on chromosome 6 encoding proteins involved in pattern formation. These proteins contain a characteristic DNA-binding motif called a homeodomain and function in transcriptional regulation. There are four distinct clusters of related genes on chromosomes 2, 6, 11, and 15. The protein encoded by this gene is important in the development of the skeleton, limbs, and urogenital tract. Expression of this gene may be regulated by overlapping transcription from an adjacent locus on the opposite strand (GeneID: 15397). [provided by RefSeq, Mar 2013]
Details
| Type | Protein Coding |
| Official Symbol | Hoxa11 |
| Official Name | homeobox A11 [Source:MGI Symbol;Acc:MGI:96172] |
| Ensembl ID | ENSMUSG00000038210 |
| Bio databases IDs | |
| Aliases | homeobox A11 |
| Synonyms | homeobox A11, HOX1, Hox-1.9, HOX1I, Hoxa10, LOC100911743, RGD1564605, RGD1566402, RUSAT1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Hoxa11 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- double-stranded DNA binding
- Protein of unknown function (DUF3528)
- protein binding
- sequence-specific DNA binding
- homeodomain
- DNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- radioulnar synostosis with amegakaryocytic thrombocytopenia type 1
- hypoplasia
- organismal death
- hypertension
- infertility condition
- cryptorchidism
- syndactyly
- azoospermia
- major depression
- uterine serous papillary cancer
role in cell
- apoptosis
- expression in
- migration
- proliferation
- growth
- specification
- osteogenic differentiation
- colony formation by
- development
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Hoxa11 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to estrogen stimulus
- male gonad development
- uterus development
- anatomical structure development
- anterior/posterior pattern specification
- chondrocyte development
- anatomical structure morphogenesis
- single fertilization
- proximal/distal pattern formation
- embryonic digit morphogenesis
- dorsal/ventral pattern formation
- embryonic limb morphogenesis
- skeletal system development
- positive regulation of transcription, DNA-dependent
- response to testosterone stimulus
- embryonic forelimb morphogenesis
- embryonic skeletal joint morphogenesis
- spermatogenesis
- cartilage development involved in endochondral bone morphogenesis
- developmental growth
- regulation of transcription from RNA polymerase II promoter
- mesodermal cell fate specification
- metanephros development
- branching involved in ureteric bud morphogenesis
- organ induction
- positive regulation of cell development
- positive regulation of chondrocyte differentiation
- prostate gland development
Cellular Component
Where in the cell the gene product is active
- nucleus
- transcription factor complex
- protein-DNA complex
- macromolecular complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity