Pbx3 Gene Summary [Mouse]
Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including adult locomotory behavior; nervous system development; and regulation of respiratory gaseous exchange by nervous system process. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; branchial arch; genitourinary system; nervous system; and sensory organ. Orthologous to human PBX3 (PBX homeobox 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pbx3 |
| Official Name | pre B cell leukemia homeobox 3 [Source:MGI Symbol;Acc:MGI:97496] |
| Ensembl ID | ENSMUSG00000038718 |
| Bio databases IDs | |
| Aliases | pre B cell leukemia homeobox 3 |
| Synonyms | LOC102551296, LOC107984127, LOC679801, PBX3B, PBX homeobox 3, pre B cell leukaemia homeobox 3, pre B cell leukemia homeobox 3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pbx3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- PBC domain
- nucleic acid binding
- double-stranded DNA binding
- protein binding
- sequence-specific DNA binding
- homeodomain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cyanosis
- respiratory failure
- congenital malformation
- hypoplasia
- leukemogenesis
- acute myeloid leukemia
- cleft palate
- lung squamous cell carcinoma
- squamous cell lung cancer
- respiratory depression
role in cell
- expression in
- cell viability
- apoptosis
- proliferation
- activity
- transformation
- development
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- chromatin
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pbx3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- dorsal spinal cord development
- posterior compartment specification
- adult locomotory behavior
- embryonic organ development
- neuron development
- respiratory gaseous exchange
- brain development
- regulation of respiratory gaseous exchange by neurological system process
- anterior compartment pattern formation
- positive regulation of transcription from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
- organ morphogenesis
- eye development
Cellular Component
Where in the cell the gene product is active
- transcription factor complex
- nucleus
- chromatin
Molecular Function
What the gene product does at the molecular level
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity