Etf1 Gene Summary [Mouse]
Predicted to enable peptidyl-tRNA hydrolase activity; sequence-specific mRNA binding activity; and translation release factor activity, codon specific. Predicted to be involved in cytoplasmic translational termination and regulation of translational termination. Predicted to act upstream of or within protein methylation. Predicted to be located in cytoplasm. Predicted to be part of translation release factor complex. Predicted to be active in cytosolic ribosome. Is expressed in central nervous system; early embryo; and retina. Orthologous to human ETF1 (eukaryotic translation termination factor 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Etf1 |
| Official Name | eukaryotic translation termination factor 1 [Source:MGI Symbol;Acc:MGI:2385071] |
| Ensembl ID | ENSMUSG00000024360 |
| Bio databases IDs | |
| Aliases | eukaryotic translation termination factor 1 |
| Synonyms | AI463371, Cl1, D5S1995, D6Ertd109e, ERF, ERF1, eukaryotic translation termination factor 1, MGC18745, RF1, SUP45L1, TB3-1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Etf1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- eRF1 domain 3
- mRNA binding
- aminoacyl-tRNA hydrolase
- eRF1 domain 1
- ribosome binding
- translation termination factor
- peptide chain release factor 1, archaeal and eukaryotic forms
- protein binding
- eRF1 domain 2
- translation release factor
- translation regulator
- RNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- ribosome
- cytosol
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Etf1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- translational termination
- regulation of translational termination
- nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
- cytoplasmic translational termination
- protein methylation
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosolic ribosome
- cytoplasm
- cytosol
- translation release factor complex
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA binding
- translation release factor activity
- ribosome binding
- aminoacyl-tRNA hydrolase activity
- translation termination factor activity
- translation release factor activity, codon specific