Iws1 Gene Summary [Mouse]
Acts upstream of or within in utero embryonic development. Is active in nucleus. Is expressed in several structures, including alimentary system; early conceptus; genitourinary system; hemolymphoid system; and nervous system. Orthologous to human IWS1 (interacts with SUPT6H, CTD assembly factor 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Iws1 |
| Official Name | IWS1, SUPT6 interacting protein [Source:MGI Symbol;Acc:MGI:1920723] |
| Ensembl ID | ENSMUSG00000024384 |
| Bio databases IDs | |
| Aliases | IWS1, SUPT6 interacting protein |
| Synonyms | 1700069O15RIK, 3000008H23, AW214353, interacts with SUPT6H, CTD assembly factor 1, IWS1, SUPT6 interacting protein, RGD1304762 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Iws1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- TFIIS helical bundle-like domain
- TFIIS_I
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- deep vein thrombosis
- pulmonary embolism
- thromboembolism
- heart disease
- pulmonary infarction
- aortic valve calcification
- non-small cell lung cancer
role in cell
- remodeling
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Iws1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- chromatin remodeling
- RNA splicing
- regulation of mRNA processing
- mRNA processing
- regulation of mRNA export from nucleus
- poly(A)+ mRNA export from nucleus
Cellular Component
Where in the cell the gene product is active
- nucleus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding