Akt3 Gene Summary [Mouse]
Enables protein serine/threonine kinase activity. Involved in negative regulation of PERK-mediated unfolded protein response; positive regulation of angiogenesis; and positive regulation of artery morphogenesis. Acts upstream of or within several processes, including brain morphogenesis; positive regulation of TOR signaling; and positive regulation of cell size. Predicted to be located in plasma membrane. Is expressed in several structures, including genitourinary system; gut; integumental system; nervous system; and retina. Human ortholog(s) of this gene implicated in colon cancer; glioblastoma; prostate adenocarcinoma; prostate cancer; and renal cell carcinoma. Orthologous to human AKT3 (AKT serine/threonine kinase 3). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Akt3 |
| Official Name | thymoma viral proto-oncogene 3 [Source:MGI Symbol;Acc:MGI:1345147] |
| Ensembl ID | ENSMUSG00000019699 |
| Bio databases IDs | |
| Aliases | thymoma viral proto-oncogene 3 |
| Synonyms | AKT serine/threonine kinase 3, D930002M15Rik, MPPH, MPPH2, Nmf350, PKBG, PKB-GAMMA, PKB-γ, PRKBG, Protein kinase Akt-3, RAC-gamma, RAC-PK-gamma, RAC-PK-γ, RAC-γ, STK-2, thymoma viral proto-oncogene 3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Akt3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- pleckstrin Homology binding region
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- protein kinase
- Protein kinase C terminal domain
- Protein tyrosine and serine/threonine kinase
- protein kinase C binding
- ATP binding
- protein binding
- Pleckstrin homology-like domain
- Protein kinase domain
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- Protein Kinases, catalytic domain
- Extension to Ser/Thr-type protein kinases
- PH domain
- cytosolic tail domain
- Tyrosine kinase, catalytic domain
Pathways
Biological processes and signaling networks where the Akt3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Apelin Cardiac Fibroblast Signaling Pathway
- Apelin Muscle Signaling Pathway
- Cancer Drug Resistance By Drug Efflux
- CXCR4 Signaling
- DNA damage-induced 14-3-3σ Signaling
- Docosahexaenoic Acid (DHA) Signaling
- FGF Signaling
- FLT3 Signaling in Hematopoietic Progenitor Cells
- Glucocorticoid Receptor Signaling
- GM-CSF Signaling
- GP6 Signaling Pathway
- HER-2 Signaling in Breast Cancer
- HGF Signaling
- IGF-1 Signaling
- IL-22 Signaling
- JAK/Stat Signaling
- Mouse Embryonic Stem Cell Pluripotency
- Polyamine Regulation in Colon Cancer
- Prostate Cancer Signaling
- PXR/RXR Activation
- RANK Signaling in Osteoclasts
- Sphingosine-1-phosphate Signaling
- Systemic Lupus Erythematosus Signaling
- Thyroid Cancer Signaling
- TR/RXR Activation
- VEGF Family Ligand-Receptor Interactions
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- non-Hodgkin lymphoma
- thrombosis
- prostate cancer
- premenopausal breast cancer
- postmenopausal breast cancer
- metastatic breast cancer
- metastatic invasive breast cancer
- invasive breast cancer
- locally advanced breast cancer
role in cell
- quantity
- expression in
- phosphorylation in
- fragmentation in
- survival
- apoptosis
- activation in
- fragmentation
- growth
- transmembrane potential
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cell center
- cilia
- cellular membrane
- Plasma Membrane
- basal bodies
- Golgi Apparatus
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Akt3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- brain morphogenesis
- positive regulation of cell migration involved in sprouting angiogenesis
- protein phosphorylation
- positive regulation of blood vessel endothelial cell migration
- positive regulation of angiogenesis
- mitochondrial genome maintenance
- positive regulation of cell size
- homeostasis of number of cells within a tissue
- positive regulation of endothelial cell proliferation
- peptidyl-serine phosphorylation
- positive regulation of TOR signaling cascade
- intracellular signal transduction
- negative regulation of cellular senescence
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- membrane
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- protein kinase activity
- protein serine/threonine kinase activity