Cxxc1 Gene Summary [Mouse]
Enables methylated histone binding activity. Predicted to be involved in positive regulation of DNA-templated transcription. Located in nuclear matrix. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; limb; and retina. Orthologous to human CXXC1 (CXXC finger protein 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Retained Intron |
| Official Symbol | Cxxc1 |
| Official Name | CXXC finger 1 (PHD domain) [Source:MGI Symbol;Acc:MGI:1921572] |
| Ensembl ID | ENSMUSG00000024560 |
| Bio databases IDs | |
| Aliases | CXXC finger 1 (PHD domain) |
| Synonyms | 2410002I16Rik, 5830420C16Rik, CFP1, CGBP, CXXC finger protein 1, hCGBP, HsT2645, PCCX1, PHF18, SPP1, ZCGPC1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cxxc1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PHD zinc finger
- histone binding
- transcription regulator
- nucleic acid binding
- coiled-coil domain
- protein binding
- sequence-specific DNA binding
- acidic domain
- unmethylated CpG binding
- CpG binding protein C-terminal domain
- double-stranded DNA binding
- PHD finger superfamily
- CXXC zinc finger domain
- basic domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear matrix fraction
- cytosol
- nucleoplasm
- nuclear speckles
- nuclear matrix
- euchromatin compartments
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cxxc1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of transcription, DNA-dependent
- regulation of transcription, DNA-dependent
Cellular Component
Where in the cell the gene product is active
- Set1C/COMPASS complex
- nucleus
- nuclear speck
- histone methyltransferase complex
- cytosol
- nuclear matrix
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- protein binding
- methylated histone residue binding
- core promoter proximal region sequence-specific DNA binding
- unmethylated CpG binding