Pola2 Gene Summary [Mouse]
Predicted to enable DNA-directed DNA polymerase activity. Involved in DNA replication initiation and DNA replication, synthesis of primer. Acts upstream of or within DNA replication and protein import into nucleus. Located in nucleus. Part of alpha DNA polymerase:primase complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and sensory organ. Orthologous to human POLA2 (DNA polymerase alpha 2, accessory subunit). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pola2 |
| Official Name | polymerase (DNA directed), alpha 2 [Source:MGI Symbol;Acc:MGI:99690] |
| Ensembl ID | ENSMUSG00000024833 |
| Bio databases IDs | |
| Aliases | polymerase (DNA directed), alpha 2 |
| Synonyms | DNA polymerase alpha 2, accessory subunit, DNA polymerase α 2, accessory subunit, p68, POL2A, polymerase (DNA directed), alpha 2, polymerase (DNA directed), α 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pola2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- DNA-directed DNA polymerase
- DNA polymerase alpha subunit B N-terminal
- DNA polymerase alpha/epsilon subunit B
- enzyme
- protein binding
Pathways
Biological processes and signaling networks where the Pola2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- pancreatic carcinoma
- pancreatic epithelial cancer
- telomere syndrome
- colorectal cancer
- plexiform neurofibroma
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- intracellular membrane-bounded organelle
- Cytoplasm
- basal bodies
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pola2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA-dependent DNA replication initiation
- DNA replication
- protein import into nucleus
- DNA replication, synthesis of RNA primer
Cellular Component
Where in the cell the gene product is active
- alpha DNA polymerase:primase complex
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding