Ptk7 Gene Summary [Mouse]
Acts upstream of or within several processes, including cochlea morphogenesis; heart development; and morphogenesis of an epithelium. Located in cell-cell junction and plasma membrane. Is expressed in several structures, including alimentary system; nervous system; paraxial mesenchyme; reproductive system; and sensory organ. Orthologous to human PTK7 (protein tyrosine kinase 7 (inactive)). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Ptk7 |
| Official Name | PTK7 protein tyrosine kinase 7 [Source:MGI Symbol;Acc:MGI:1918711] |
| Ensembl ID | ENSMUSG00000023972 |
| Bio databases IDs | |
| Aliases | PTK7 protein tyrosine kinase 7 |
| Synonyms | 8430404F20Rik, CCK-4, chz, mPTK7/CCK4, Otk, protein tyrosine kinase 7, protein tyrosine kinase 7 (inactive), PTK7 protein tyrosine kinase 7 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ptk7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- Immunoglobulin C1-set domain
- Protein kinase (unclassified specificity)
- Protein tyrosine and serine/threonine kinase
- immunoglobulin domain
- Immunoglobulin I-set domain
- protein binding
- protein-tyrosine kinase
- Protein kinase domain
- kinase
- Serine/Threonine protein kinases, catalytic domain
- Protein Kinases, catalytic domain
- Immunoglobulin like
- Tyrosine kinase, catalytic domain
- Immunoglobulin V-set domain
Pathways
Biological processes and signaling networks where the Ptk7 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cutaneous melanoma
- cutaneous melanoma cancer
- congenital heart disease
- COVID-19
- HER2 negative hormone receptor negative breast cancer
- coronary artery disease
- early missed abortion
- breast cancer
- congenital posterior urethral valve disorder
role in cell
- expression in
- phosphorylation in
- activation in
- proliferation
- quantity
- migration
- organization
- development
- invasion by
- response by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- intracellular membrane-bounded organelle
- cellular membrane
- intercellular junctions
- cytosol
- filopodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ptk7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- lung-associated mesenchyme development
- planar cell polarity pathway involved in neural tube closure
- synapse organization
- signal transduction
- cochlea morphogenesis
- ventricular septum development
- positive regulation of canonical Wnt receptor signaling pathway
- coronary vasculature development
- axon guidance
- homophilic cell adhesion
- convergent extension
- axis elongation
- wound healing
- kidney development
- cellular response to retinoic acid
- regulation of canonical Wnt receptor signaling pathway
- establishment of epithelial cell apical/basal polarity
- establishment of planar polarity
- positive regulation of neuron projection development
- actin cytoskeleton organization
- cell migration
Cellular Component
Where in the cell the gene product is active
- cell-cell junction
- focal adhesion
- neuronal cell body
- axon
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- ATP binding
- coreceptor activity
- protein binding
- protein kinase activity
- axon guidance receptor activity