Tnxb Gene Summary [Mouse]
Enables collagen binding activity and heparin binding activity. Acts upstream of or within several processes, including collagen fibril organization; regulation of JNK cascade; and triglyceride metabolic process. Located in extracellular matrix and extracellular space. Is expressed in several structures, including alimentary system; endocrine gland; genitourinary system; heart and pericardium; and immune system. Human ortholog(s) of this gene implicated in Ehlers-Danlos syndrome; Ehlers-Danlos syndrome classic-like 1; and vesicoureteral reflux. Orthologous to several human genes including TNXB (tenascin XB). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tnxb |
| Official Name | tenascin XB [Source:MGI Symbol;Acc:MGI:1932137] |
| Ensembl ID | ENSMUSG00000033327 |
| Bio databases IDs | |
| Aliases | tenascin XB |
| Synonyms | EDS3, EDSCLL, EDSCLL1, Hs.534359, HXBL, LOC101060681, Tenascin-X, TENASCIN XA, Tenascin-Xb, TENX, Tn-mhc, TN-X, TNXB1, TNXB2, TNXBS, VUR8, XB, XBS |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tnxb often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- FN3
- extracellular matrix binding
- integrin binding
- Keratin, high sulfur B2 protein
- extracellular matrix structural constituent
- collagen binding
- protein binding
- Fibronectin type 3 domain
- heparin binding
- FReD
- Tenascin EGF domain
- EGF_CA
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- human immunodeficiency virus I infection
- rheumatoid arthritis
- COVID-19
- cervical carcinoma
- lung squamous cell carcinoma
- squamous cell lung cancer
- psoriasis
- endometrial cancer
- neuroticism
- cervical cancer
role in cell
- adhesion
- proliferation
- density
- expression in
- activation
- organization
- abnormal morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- intracellular membrane-bounded organelle
- extracellular matrix
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tnxb gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell-matrix adhesion
- neuron projection development
- positive regulation of cell proliferation
- triglyceride metabolic process
- cell adhesion
- fatty acid metabolic process
- positive regulation of epithelial to mesenchymal transition
- positive regulation of vascular endothelial growth factor signaling pathway
- elastic fiber assembly
- regulation of cell differentiation
- regulation of cell adhesion
- collagen fibril organization
- regulation of cell migration
- actin cytoskeleton organization
- collagen metabolic process
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular vesicular exosome
- intracellular membrane-bounded organelle
- extracellular matrix
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding
- collagen binding
- integrin binding
- heparin binding
- extracellular matrix structural constituent