Pycr1 Gene Summary [Mouse]
Predicted to enable identical protein binding activity and pyrroline-5-carboxylate reductase activity. Predicted to be involved in several processes, including L-proline biosynthetic process; negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway; and regulation of mitochondrial membrane potential. Located in mitochondrion. Is expressed in several structures, including alimentary system; brain; ear; genitourinary system; and skeleton. Human ortholog(s) of this gene implicated in autosomal recessive cutis laxa type IIB and autosomal recessive cutis laxa type IIIB. Orthologous to human PYCR1 (pyrroline-5-carboxylate reductase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pycr1 |
| Official Name | pyrroline-5-carboxylate reductase 1 [Source:MGI Symbol;Acc:MGI:2384795] |
| Ensembl ID | ENSMUSG00000025140 |
| Bio databases IDs | |
| Aliases | pyrroline-5-carboxylate reductase 1 |
| Synonyms | ARCL2B, ARCL3B, P5C, P5CR, P5CR 1, PIG45, PP222, PRO3, PYCR, pyrroline-5-carboxylate reductase 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pycr1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Rossmann-fold NAD(P)(+)-binding proteins
- pyrroline-5-carboxylate reductase
- NADP oxidoreductase coenzyme F420-dependent
- enzyme
- protein binding
- Pyrroline-5-carboxylate reductase dimerization
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- liver cancer
- epithelial cancer
- organismal death
- autosomal recessive cutis laxa type 3B
- hepatocellular carcinoma
- autosomal recessive cutis laxa type 2B
- hereditary disorder
- cutis laxa
- lung adenocarcinoma
role in cell
- expression in
- proliferation
- apoptosis
- migration
- phosphorylation in
- invasion by
- response by
- synthesis in
- fragmentation in
- G1 phase
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- Mitochondria
- mitochondrial matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pycr1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of mitochondrial membrane potential
- cellular response to oxidative stress
- proline biosynthetic process
- L-proline biosynthetic process
Cellular Component
Where in the cell the gene product is active
- mitochondrial matrix
- mitochondrion
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- pyrroline-5-carboxylate reductase activity
- protein binding