Poll Gene Summary [Mouse]
Enables DNA-directed DNA polymerase activity. Predicted to be involved in DNA metabolic process. Predicted to be located in nucleoplasm. Predicted to be active in nucleus and site of double-strand break. Is expressed in muscle tissue; retina; and seminiferous tubule. Orthologous to human POLL (DNA polymerase lambda). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Poll |
| Official Name | polymerase (DNA directed), lambda [Source:MGI Symbol;Acc:MGI:1889000] |
| Ensembl ID | ENSMUSG00000025218 |
| Bio databases IDs | |
| Aliases | polymerase (DNA directed), lambda |
| Synonyms | 1110003P06Rik, BETAN, DNA polymerase lambda, DNA polymerase λ, POLKAPPA, polymerase (DNA directed), lambda, polymerase (DNA directed), λ, Pol-κ, β-n |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Poll often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Helix-hairpin-helix domain
- BRCT
- DNA polymerase beta thumb
- DNA-directed DNA polymerase
- Nucleotidyltransferase (NT) domain of DNA polymerase beta and similar proteins
- Fingers domain of DNA polymerase lambda
- DNA polymerase X family
- enzyme
- protein binding
- DNA polymerase beta palm
- carbon-oxygen lyase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- chronic suppurative sinusitis
- situs inversus totalis
- hydrocephalus
- infection by HIV
regulates
- nucleotide
- DNA polymerase
- POLL
- 5'-deoxyribose phosphate
- adenine
role in cell
- cell viability
- proliferation
- cell movement
- quantity
- differentiation
- number
- growth
- replication
- morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear foci
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Poll gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA replication
- DNA biosynthetic process
- double-strand break repair via homologous recombination
- nucleotide-excision repair
- base-excision repair, gap-filling
- double-strand break repair via nonhomologous end joining
- somatic hypermutation of immunoglobulin genes
Cellular Component
Where in the cell the gene product is active
- nucleus
- site of double-strand break
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- DNA-directed DNA polymerase activity
- 5'-deoxyribose-5-phosphate lyase activity
- protein binding
- metal ion binding