Tbrg4 Gene Summary [Mouse]
Predicted to enable RNA binding activity. Predicted to be involved in mitochondrial mRNA processing and regulation of mitochondrial mRNA stability. Located in mitochondrion. Is expressed in axial musculature; germ cell of testis; ovary; and seminiferous cord. Orthologous to human TBRG4 (transforming growth factor beta regulator 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | Tbrg4 |
| Official Name | transforming growth factor beta regulated gene 4 [Source:MGI Symbol;Acc:MGI:1100868] |
| Ensembl ID | ENSMUSG00000000384 |
| Bio databases IDs | |
| Aliases | transforming growth factor beta regulated gene 4 |
| Synonyms | 2310042P22Rik, AI527316, CPR2, FASTKD4, LOC100046166, Tb-12, transforming growth factor beta regulated gene 4, transforming growth factor beta regulator 4, transforming growth factor β regulated gene 4, transforming growth factor β regulator 4 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tbrg4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- FAST kinase-like protein, subdomain 1
- RNA-editing substrate-binding complex subunit 6 (RESC6) and related proteins
- FAST kinase-like protein, subdomain 2
- protein binding
- PDDEXK family nucleases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colorectal cancer
role in cell
- expression in
- proliferation
- growth
- migration
- binding in
- invasion by
- cell cycle progression
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- mitochondrial matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tbrg4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of mitochondrial mRNA stability
- mRNA metabolic process
- positive regulation of cell proliferation
- regulation of cell cycle
- mitochondrial RNA processing
Cellular Component
Where in the cell the gene product is active
- ribonucleoprotein granule
- mitochondrial matrix
- mitochondrion
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA binding