Apex2 Gene Summary [Mouse]
Predicted to enable DNA-(apurinic or apyrimidinic site) endonuclease activity; double-stranded DNA 3'-5' DNA exonuclease activity; and phosphoric diester hydrolase activity. Predicted to be involved in base-excision repair. Located in mitochondrial inner membrane and nucleus. Orthologous to human APEX2 (apurinic/apyrimidinic endodeoxyribonuclease 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Apex2 |
| Official Name | apurinic/apyrimidinic endonuclease 2 [Source:MGI Symbol;Acc:MGI:1924872] |
| Ensembl ID | ENSMUSG00000025269 |
| Bio databases IDs | |
| Aliases | apurinic/apyrimidinic endonuclease 2 |
| Synonyms | APE2, APEXL2, apurinic/apyrimidinic endodeoxyribonuclease 2, apurinic/apyrimidinic endonuclease 2, C430040P13Rik, XTH2, ZGRF2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Apex2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily
- Endonuclease/Exonuclease/phosphatase family
- GRF zinc finger
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- fibrillar center
- intracellular membrane-bounded organelle
- Mitochondria
- mitochondrial inner membrane
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Apex2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- base-excision repair
- DNA recombination
Cellular Component
Where in the cell the gene product is active
- nucleus
- intracellular membrane-bounded organelle
- mitochondrion
- fibrillar center
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- zinc ion binding
- protein binding
- endonuclease activity
- double-stranded DNA specific 3'-5' exodeoxyribonuclease activity
- DNA-(apurinic or apyrimidinic site) lyase activity
- phosphoric diester hydrolase activity