Padi3 Gene Summary [Mouse]
Predicted to enable identical protein binding activity and protein-arginine deiminase activity. Predicted to be involved in chromatin remodeling. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in cytoplasm and nucleus. Is expressed in blastocyst; early embryo; ganglia; oocyte; and vibrissa. Orthologous to human PADI3 (peptidyl arginine deiminase 3). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Padi3 |
| Official Name | peptidyl arginine deiminase, type III [Source:MGI Symbol;Acc:MGI:1338891] |
| Ensembl ID | ENSMUSG00000025328 |
| Bio databases IDs | |
| Aliases | peptidyl arginine deiminase, type III |
| Synonyms | mKIAA4171, PAD3, PDI3, peptidyl arginine deiminase 3, Peptidylarginine deiminase III, peptidyl arginine deiminase, type III, PEPTIDYLARGININE DEIMINASE type III, UHS1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Padi3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein-arginine deiminase
- Protein-arginine deiminase (PAD) N-terminal domain
- Cupredoxin superfamily
- Protein-arginine deiminase (PAD)
- enzyme
- protein binding
- Protein-arginine deiminase (PAD) middle domain
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- rheumatoid arthritis
- uncombable hair syndrome 1
- central centrifugal cicatricial alopecia
- androgenic alopecia
regulates
- DNA promoter
- DNA endogenous promoter
- histone H3
- histone H4
- PADI3
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Padi3 gene, providing context for its role in the cell.
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- intracellular membrane-bounded organelle
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein-arginine deiminase activity
- protein binding
- calcium ion binding