Fscn2 Gene Summary [Mouse]
Predicted to enable actin filament binding activity. Acts upstream of or within eye photoreceptor cell development. Located in actin cytoskeleton and stereocilium. Is expressed in retina. Used to study auditory system disease; retinal degeneration; and retinitis pigmentosa 30. Human ortholog(s) of this gene implicated in retinitis pigmentosa and retinitis pigmentosa 30. Orthologous to human FSCN2 (fascin actin-bundling protein 2, retinal). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fscn2 |
| Official Name | fascin actin-bundling protein 2 [Source:MGI Symbol;Acc:MGI:2443337] |
| Ensembl ID | ENSMUSG00000025380 |
| Bio databases IDs | |
| Aliases | fascin actin-bundling protein 2 |
| Synonyms | A930022G03, Ahl8, C630046B20Rik, fascin actin-bundling protein 2, fascin actin-bundling protein 2, retinal, RFSN, RP30 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Fscn2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- actin filament binding
- fascin-like domain, beta-trefoil fold, found in the fascin-like family
- actin binding
- protein binding
- Fascin domain
Pathways
Biological processes and signaling networks where the Fscn2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- retinal dystrophy
- age-related hearing loss
- autosomal dominant retinitis pigmentosa
- retinitis pigmentosa type 30
- progressive high frequency hearing impairment
- macular degeneration
- hearing loss
phenotypes
- abnormal auditory brainstem response
- abnormal cochlear hair cell stereociliary bundle morphology
- abnormal cochlear outer hair cell physiology
- abnormal cone electrophysiology
- abnormal distortion product otoacoustic emission
- abnormal eye electrophysiology
- abnormal photoreceptor inner segment morphology
- abnormal photoreceptor outer segment morphology
- abnormal photoreceptor outer segment size
- abnormal retina morphology
- abnormal rod electrophysiology
- abnormal vision
- cochlear outer hair cell degeneration
- decreased a wave amplitude
- decreased b wave amplitude
- decreased inner hair cell stereocilia number
- decreased outer hair cell stereocilia number
- decreased total retina thickness
- impaired hearing
- increased or absent threshold for auditory brainstem response
- increased susceptibility to age-related hearing loss
- photoreceptor inner segment degeneration
- photoreceptor outer segment degeneration
- retinal degeneration
- retinal outer nuclear layer degeneration
- short cochlear hair cell stereocilia
- short photoreceptor outer segment
- thin retinal inner nuclear layer
- thin retinal outer nuclear layer
role in cell
- development
- width
- shortening
- abnormal morphology
- electrophysiology
- length
- shortening in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- actin cytoskeleton
- cytosol
- stereocilia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Fscn2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- establishment or maintenance of cell polarity
- eye photoreceptor cell development
- anatomical structure morphogenesis
- visual perception
- cell migration
- actin cytoskeleton organization
- actin filament bundle assembly
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- actin cytoskeleton
- stereocilium
Molecular Function
What the gene product does at the molecular level
- actin filament binding
- protein binding
- actin binding
- protein binding, bridging