Tmc6 Gene Summary [Mouse]
Predicted to enable mechanosensitive monoatomic ion channel activity. Involved in protein stabilization. Predicted to be located in Golgi apparatus; endoplasmic reticulum; and nuclear membrane. Human ortholog(s) of this gene implicated in epidermodysplasia verruciformis. Orthologous to human TMC6 (transmembrane channel like 6). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | Tmc6 |
| Official Name | transmembrane channel-like gene family 6 [Source:MGI Symbol;Acc:MGI:1098686] |
| Ensembl ID | ENSMUSG00000025572 |
| Bio databases IDs | |
| Aliases | transmembrane channel-like gene family 6 |
| Synonyms | AABR07030861.1, D11Ertd204e, EV1, EVER1, EVIN1, LAK-4P, lnc, Loc217353, TNRC6C-AS1, transmembrane channel like 6, transmembrane channel-like gene family 6 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tmc6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Calcium-activated chloride channel
- protein binding
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diabetes mellitus
- metastasis
- non-insulin-dependent diabetes mellitus
- epidermodysplasia verruciformis
- susceptibility to epidermodysplasia verruciformis type 1
- cervical intraepithelial neoplasia
role in cell
- expression in
- growth
- morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Plasma Membrane
- Golgi Apparatus
- Endoplasmic Reticulum
- tertiary granule membrane
- specific granule membrane
- endoplasmic reticulum membrane
- nuclear envelope
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tmc6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ion transmembrane transport
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- nuclear membrane
- extracellular vesicular exosome
- cytoplasm
- endoplasmic reticulum
- Golgi apparatus
- plasma membrane
- tertiary granule membrane
- specific granule membrane
Molecular Function
What the gene product does at the molecular level
- mechanically-gated ion channel activity
- protein binding