Pxk Gene Summary [Mouse]
Predicted to enable several functions, including ATP binding activity; actin binding activity; and phosphatidylinositol binding activity. Involved in modulation of chemical synaptic transmission; negative regulation of ATP-dependent activity; and negative regulation of monoatomic ion transport. Located in cytoplasm and plasma membrane. Part of protein-containing complex. Is expressed in brain and spinal cord. Orthologous to human PXK (PX domain containing serine/threonine kinase like). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pxk |
| Official Name | PX domain containing serine/threonine kinase [Source:MGI Symbol;Acc:MGI:1289230] |
| Ensembl ID | ENSMUSG00000033885 |
| Bio databases IDs | |
| Aliases | PX domain containing serine/threonine kinase |
| Synonyms | C230080L11Rik, D14ERTD813E, MONAKA, PX domain containing serine/threonine kinase, PX domain containing serine/threonine kinase like, SLOB |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pxk often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- protein serine/threonine kinase
- Protein Kinases, catalytic domain
- WH2
- phosphatidylinositol-3-phosphate binding domain
- The Phox Homology domain, a phosphoinositide binding module
- protein binding
- PX domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- systemic lupus erythematosus
- insulin-dependent diabetes mellitus
- hypercholesterolemia
- systemic sclerosis
role in cell
- degradation in
- ubiquitination in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Nucleus
- Plasma Membrane
- centrosome
- cytosol
- recycling endosomes
- early endosomes
- late endosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pxk gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- inflammatory response
- negative regulation of ion transport
- negative regulation of ATPase activity
- early endosome to late endosome transport
- regulation of synaptic transmission
- endosome to lysosome transport
- protein phosphorylation
- protein targeting to lysosome
Cellular Component
Where in the cell the gene product is active
- early endosome
- cytoplasm
- centriolar satellite
- late endosome
- cytosol
- macromolecular complex
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- nucleotide binding
- ATP binding
- actin binding
- phosphatidylinositol binding
- protein kinase activity