Nmb Gene Summary [Rat]
Enables neuromedin B receptor binding activity. Involved in several processes, including arachidonate secretion; positive regulation of cytosolic calcium ion concentration; and regulation of hormone secretion. Predicted to be located in extracellular space. Predicted to be active in neuron projection. Biomarker of obesity. Human ortholog(s) of this gene implicated in obesity. Orthologous to human NMB (neuromedin B). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nmb |
| Official Name | neuromedin B [Source:RGD Symbol;Acc:1562710] |
| Ensembl ID | ENSRNOG00000011011 |
| Bio databases IDs | |
| Aliases | neuromedin B |
| Synonyms | 3110023K12Rik, Neuromedin b, RGD1562710 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Nmb often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Bombesin-like peptide
- G-protein-coupled receptor binding
- hormone
- protein binding
Pathways
Biological processes and signaling networks where the Nmb gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- dilated cardiomyopathy
- sneeze
- glioblastoma
- glioblastoma cancer
- small cell lung cancer
role in cell
- proliferation
- depolarization
- elevation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- neurites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Nmb gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of interleukin-6 production
- positive regulation of interferon-alpha production
- neuropeptide signaling pathway
- arachidonic acid secretion
- positive regulation of testosterone secretion
- signal transduction
- cell-cell signaling
- positive regulation of hormone secretion
- negative regulation of hormone secretion
- positive regulation of osteoclast proliferation
- elevation of cytosolic calcium ion concentration
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular region
- neuron projection
Molecular Function
What the gene product does at the molecular level
- protein binding
- neuropeptide hormone activity
- neuromedin B receptor binding
- hormone activity