Ccrl2 Gene Summary [Mouse]
Enables chemokine receptor binding activity. Involved in inflammatory response. Predicted to be located in plasma membrane. Predicted to be active in cytoplasm and external side of plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; immune system; and liver and biliary system. Orthologous to human CCRL2 (C-C motif chemokine receptor like 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ccrl2 |
| Official Name | chemokine (C-C motif) receptor-like 2 [Source:MGI Symbol;Acc:MGI:1920904] |
| Ensembl ID | ENSMUSG00000043953 |
| Bio databases IDs | |
| Aliases | chemokine (C-C motif) receptor-like 2 |
| Synonyms | 1810047I05Rik, ACKR5, alpha HELIX COILED-COIL ROD HOMOLOG, C-C motif chemokine receptor-like 2, CCR11, Chemokine receptor-like 2, CHEMOKINE receptor X, CKRX, Cmkbr1l2, CRAM, E01, HCR, L-CCR, LOC727811, LPS-Inducible C-C Chemokine Receptor Related, α HELIX COILED-COIL ROD HOMOLOG |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ccrl2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- C-C chemokine receptor
- Cholecystokinin A receptor, N-terminal
- chemokine receptor
- CCR chemokine receptor binding
- chemokine receptor binding
- 7 transmembrane receptor (rhodopsin family)
- protein binding
- seven-transmembrane G protein-coupled receptor superfamily
Pathways
Biological processes and signaling networks where the Ccrl2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- cancer
- human immunodeficiency virus I infection
- papillomatosis
- epithelial neoplasia
- benign neoplasia
- obesity
- rheumatoid arthritis
- diabetes mellitus
- non-insulin-dependent diabetes mellitus
role in cell
- expression in
- accumulation in
- migration
- function
- chemotaxis
- recruitment
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ccrl2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- chemotaxis
- inflammatory response
- immune response
- G-protein coupled receptor signaling pathway
- chemokine-mediated signaling pathway
- calcium-mediated signaling
- elevation of cytosolic calcium ion concentration
- cell chemotaxis
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- external side of plasma membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- C-C chemokine binding
- CCR chemokine receptor binding
- C-C chemokine receptor activity
- chemokine receptor binding
- chemokine receptor activity