Cacnb1 Gene Summary [Mouse]

Enables high voltage-gated calcium channel activity. Acts upstream of or within calcium ion transport and protein targeting to membrane. Located in T-tubule and sarcoplasmic reticulum. Part of voltage-gated calcium channel complex. Is active in presynapse. Is expressed in several structures, including heart; lower leg rest of mesenchyme; nervous system; skeletal musculature; and urinary system. Orthologous to human CACNB1 (calcium voltage-gated channel auxiliary subunit beta 1). [provided by Alliance of Genome Resources, Jul 2025]

Details

Type
Protein Coding
Official Symbol
Cacnb1
Official Name
calcium channel, voltage-dependent, beta 1 subunit [Source:MGI Symbol;Acc:MGI:102522]
Ensembl ID
ENSMUSG00000020882
Bio databases IDs NCBI: 12295 Ensembl: ENSMUSG00000020882
Aliases calcium channel, voltage-dependent, beta 1 subunit
Synonyms CAB1, CACNLB1, Calcium Channel beta1, calcium channel, voltage-dependent, beta 1 subunit, calcium channel, voltage-dependent, β 1 subunit, calcium voltage-gated channel auxiliary subunit beta 1, calcium voltage-gated channel auxiliary subunit β 1, Cchb1, CCHLB1, Conotoxin Receptor beta1, L-type calcium channel beta1b
Species
Mouse, Mus musculus
OrthologiesHumanRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cacnb1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • protein kinase binding
  • high voltage-gated calcium channel
  • phosphoprotein binding
  • protein domain specific binding
  • protein binding
  • identical protein binding
  • ion channel
  • calcium channel regulator
  • Src Homology 3 domain superfamily
  • guanylate kinase
  • voltage-gated calcium channel
  • NK
  • Voltage gated calcium channel subunit beta domain 4Aa N terminal

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
disease
  • arrhythmia
  • atrial flutter
  • atrial fibrillation
  • heart disease
  • cardiovascular disorder
  • ventricular arrhythmia
  • bleeding
  • supraventricular tachycardia
  • cluster headache
  • hypertension
regulated by
regulates
role in cell
  • phosphorylation in
  • abnormal morphology

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Plasma Membrane
  • glutaminergic synapse
  • Cytoplasm
  • presynaptic regions
  • postsynaptic region
  • cellular membrane
  • sarcoplasmic reticulum
  • sarcolemma
  • transverse tubules
  • microsomal membrane

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the mouse Cacnb1 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • neuromuscular junction development
  • calcium ion transmembrane transport
  • synaptic transmission
  • positive regulation of muscle contraction

Cellular Component

Where in the cell the gene product is active
  • T-tubule
  • voltage-gated calcium channel complex
  • synapse
  • plasma membrane

Molecular Function

What the gene product does at the molecular level
  • protein binding
  • high voltage-gated calcium channel activity
  • voltage-gated calcium channel activity

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.