Raph1 Gene Summary [Mouse]
Acts upstream of or within axon extension. Located in cell leading edge. Is expressed in telencephalon. Orthologous to human RAPH1 (Ras association (RalGDS/AF-6) and pleckstrin homology domains 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Raph1 |
| Official Name | Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 [Source:MGI Symbol;Acc:MGI:1924550] |
| Ensembl ID | ENSMUSG00000026014 |
| Bio databases IDs | |
| Aliases | Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 |
| Synonyms | 9430025M21RIK, ALS2CR18, ALS2CR9, C730009O10Rik, KIAA1681, LAMELLIPODIN, LPD, PREL-2, RalGDS/AF-6, Ras association (RalGDS/AF-6) and pleckstrin homology domains 1, RMO1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Raph1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ras association domain
- Ubl1_cv_Nsp3_N-like
- PH domain
- protein binding
- Pleckstrin homology-like domain
- Ena/VASP-binding motif
- Sh3 domain binding motif
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- epithelial neoplasia
- cancer
- coronary artery disease
- edema
- osteoarthritis
- rectal prolapse
- organismal death
- psoriatic arthritis
- diverticular disease
role in cell
- quantity
- activation in
- migration
- development
- outgrowth
- outgrowth in
- development in
- endocytosis in
- uptake in
- disappearance in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- dendrite tip
- cytosol
- nuclear bodies
- membrane processes
- cell membrane leading edge
- dendrites
- dendritic shafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Raph1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- axon extension
Cellular Component
Where in the cell the gene product is active
- nuclear body
- cytoskeleton
- filopodium
- cytosol
- plasma membrane
- lamellipodium
Molecular Function
What the gene product does at the molecular level
- protein binding