Sema4d Gene Summary [Mouse]
Enables receptor ligand activity and semaphorin receptor binding activity. Involved in several processes, including negative regulation of osteoblast differentiation; positive regulation of Rho protein signal transduction; and positive regulation of inhibitory synapse assembly. Acts upstream of or within positive regulation of axonogenesis. Located in extracellular space. Part of semaphorin receptor complex. Is active in GABA-ergic synapse. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hemolymphoid system; and sensory organ. Orthologous to human SEMA4D (semaphorin 4D). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sema4d |
| Official Name | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D [Source:MGI Symbol;Acc:MGI:109244] |
| Ensembl ID | ENSMUSG00000021451 |
| Bio databases IDs | |
| Aliases | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D |
| Synonyms | A8, BB18, C9orf164, CD100, COLL4, GR3, LOC103694042, LOC115488166, LOC349236, M-sema-G, Semacl2, sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D, SEMAJ, semaphorin 4D, Semaphorin H, Semaphorin J, Semcl2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Sema4d often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- Immunoglobulin C1-set domain
- signaling receptor activity
- Plexin repeat
- immunoglobulin domain
- protein binding
- receptor binding
- identical protein binding
- semaphorin domain
- semaphorin receptor binding
- Immunoglobulin like
- receptor agonist activity
- Sema domain
- transmembrane receptor
- The Sema domain, a protein interacting module, of semaphorins and plexins
Pathways
Biological processes and signaling networks where the Sema4d gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- metastasis
- adenoma formation
- squamous cell cancer of the oral cavity
- experimental autoimmune encephalomyelitis
- COVID-19
- coronary artery disease
- osteosclerosis
- Alzheimer disease
- refractive error
role in cell
- expression in
- activation in
- proliferation
- apoptosis
- growth
- production in
- quantity
- binding in
- activation
- activity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- intracellular membrane-bounded organelle
- cell surface
- Extracellular Space
- cellular membrane
- basal bodies
- centrosome
- postsynaptic membrane
- nucleoplasm
- synapse
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Sema4d gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- bone trabecula morphogenesis
- regulation of cell shape
- negative chemotaxis
- positive regulation of Rho protein signal transduction
- axon guidance
- cell adhesion
- positive regulation of GTPase activity
- regulation of dendrite morphogenesis
- negative regulation of osteoblast differentiation
- negative regulation of transcription from RNA polymerase II promoter
- immune response
- leukocyte aggregation
- positive regulation of peptidyl-tyrosine phosphorylation
- negative regulation of peptidyl-tyrosine phosphorylation
- negative regulation of cell adhesion
- ossification involved in bone maturation
- positive regulation of collateral sprouting
- neural crest cell migration
- negative regulation of apoptotic process
- positive regulation of protein phosphorylation
- regulation of cell projection organization
- positive regulation of protein kinase B signaling cascade
- positive regulation of cell migration
- semaphorin-plexin signaling pathway
Cellular Component
Where in the cell the gene product is active
- extracellular space
- semaphorin receptor complex
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- transmembrane signaling receptor activity
- signaling receptor activity
- receptor agonist activity
- chemorepellent activity
- receptor binding
- semaphorin receptor binding