Wdr12 Gene Summary [Mouse]
Predicted to enable ribonucleoprotein complex binding activity. Acts upstream of or within Notch signaling pathway. Located in nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system; and integumental system. Orthologous to human WDR12 (WD repeat domain 12). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Wdr12 |
| Official Name | WD repeat domain 12 [Source:MGI Symbol;Acc:MGI:1927241] |
| Ensembl ID | ENSMUSG00000026019 |
| Bio databases IDs | |
| Aliases | WD repeat domain 12 |
| Synonyms | 4933402C23Rik, WD repeat domain 12, YTM1, Ytm1p |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Wdr12 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- NLE (NUC135) domain
- WD40 repeats
- WD domain, G-beta repeat
- WD40
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Alzheimer disease
- headache
- myocardial infarction
- non-small cell lung cancer
- coronary artery disease
- migraines
- hemolytic anemia
- non-small cell lung carcinoma
- small vessel disease stroke
- suicide attempt
regulates
- RNR
role in cell
- proliferation
- cell cycle progression
- processing in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- pre-ribosome
- Nucleus
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Wdr12 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
- Notch signaling pathway
- ribosomal large subunit biogenesis
- regulation of cell cycle
- maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Cellular Component
Where in the cell the gene product is active
- PeBoW complex
- nucleolus
- preribosome, large subunit precursor
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- ribonucleoprotein complex binding