Bop1 Gene Summary [Mouse]
Enables ribonucleoprotein complex binding activity. Involved in cell population proliferation and cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Acts upstream of or within rRNA processing. Located in nucleolus. Is expressed in several structures, including central nervous system; female reproductive system; and urinary system. Orthologous to human BOP1 (BOP1 ribosomal biogenesis factor). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Bop1 |
| Official Name | block of proliferation 1 [Source:MGI Symbol;Acc:MGI:1334460] |
| Ensembl ID | ENSMUSG00000022557 |
| Bio databases IDs | |
| Aliases | block of proliferation 1 |
| Synonyms | block of proliferation 1, BOP1 ribosomal biogenesis factor, Erb1p, Kiaa0124, LOC727967, mKIAA0124 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Bop1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Anaphase-promoting complex subunit 4 WD40 domain
- PEST domain
- WD40 repeats
- BOP1NT (NUC169) domain
- ribonucleoprotein binding
- WD domain, G-beta repeat
- WD40
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- Dupuytren contracture
- postmenopausal osteoporosis
role in cell
- proliferation
- G1 phase
- cell cycle progression
- processing in
- assembly
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- chromosome
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Bop1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell proliferation
- maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
- ribosome biogenesis
- cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
- regulation of cell cycle
- ribosomal large subunit assembly
Cellular Component
Where in the cell the gene product is active
- PeBoW complex
- chromosome
- nucleolus
- nucleoplasm
- preribosome, large subunit precursor
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA binding
- ribonucleoprotein complex binding