Cdc7 Gene Summary [Mouse]
Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in several processes, including cell cycle phase transition; double-strand break repair via break-induced replication; and positive regulation of cell cycle process. Predicted to be located in intercellular bridge; mitotic spindle; and nucleoplasm. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including gut; hemolymphoid system gland; musculature; nervous system; and sensory organ. Orthologous to human CDC7 (cell division cycle 7). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cdc7 |
| Official Name | cell division cycle 7 (S. cerevisiae) [Source:MGI Symbol;Acc:MGI:1309511] |
| Ensembl ID | ENSMUSG00000029283 |
| Bio databases IDs | |
| Aliases | cell division cycle 7 (S. cerevisiae) |
| Synonyms | CDC7L1, CDC7-RELATED KINASE, cell division cycle 7, HsCDC7, Hsk1, huCDC7, muCdc7 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cdc7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- Serine/Threonine protein kinases, catalytic domain
- protein serine/threonine kinase
- DAM-2 motif
- protein kinase
- Protein Kinases, catalytic domain
- ATP-binding domain
- nuclear retention sequence
- protein binding
- DAM-1 motif
Pathways
Biological processes and signaling networks where the Cdc7 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- invasive breast cancer
- organismal death
- liver cancer
- epithelial cancer
- preeclampsia
- lung squamous cell carcinoma
- squamous cell lung cancer
- urothelial bladder carcinoma
- transitional cell bladder cancer
- uterine leiomyoma
role in cell
- phosphorylation in
- binding in
- activation in
- apoptosis
- growth
- cell death
- binding
- cell viability
- proliferation
- cell cycle progression
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- nucleoplasmic fraction
- chromatin fraction
- Cytoplasm
- cytoplasmic bridges
- nucleoplasm
- mitotic spindle
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cdc7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- positive regulation of DNA replication involved in S phase
- double-strand break repair via break-induced replication
- signal transduction
- G1/S transition of mitotic cell cycle
- positive regulation of cell proliferation
- peptidyl-serine phosphorylation
- positive regulation of G2/M transition of mitotic cell cycle
Cellular Component
Where in the cell the gene product is active
- nucleus
- intercellular bridge
- mitotic spindle
- cytoplasm
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- metal ion binding
- protein kinase activity
- protein serine/threonine kinase activity
- kinase activity