Khdrbs2 Gene Summary [Mouse]
The protein encoded by this gene is similar to the src associated in mitosis, 68 kDa protein, which is an RNA-binding protein and a substrate for Src-family tyrosine kinases during mitosis. This protein has a KH RNA-binding motif and proline-rich motifs which may be SH2 and SH3 domain binding sites. A similar rat protein is an RNA-binding protein which is tyrosine phosphorylated by Src during mitosis. These studies also suggest that the rat protein may function as an adaptor protein for Src by binding the SH2 and SH3 domains of various other proteins. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | Khdrbs2 |
| Official Name | KH domain containing, RNA binding, signal transduction associated 2 [Source:MGI Symbol;Acc:MGI:2159649] |
| Ensembl ID | ENSMUSG00000026058 |
| Bio databases IDs | |
| Aliases | KH domain containing, RNA binding, signal transduction associated 2 |
| Synonyms | 6330586C16Rik, KH domain containing, RNA binding, signal transduction associated 2, KHDRBS2-OT, KHDRBS2-OT1, KH RNA binding domain containing, signal transduction associated 2, mSLM-1, RP1 240B83, Slim1, SLM-1, Tg(LRRK2*R1441G)135Cjli, TG-RP135 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Khdrbs2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Qua1 domain
- K homology (KH) RNA-binding domain, type I
- SH2-domain binding
- poly(A) binding protein
- protein binding
- Tyrosine-rich domain of Sam68
- SH3-domain binding
- poly(U) binding protein
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
- nuclear bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Khdrbs2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of alternative nuclear mRNA splicing, via spliceosome
- mRNA processing
Cellular Component
Where in the cell the gene product is active
- nucleus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- poly(A) RNA binding
- mRNA binding
- poly(U) RNA binding
- SH3 domain binding
- SH2 domain binding