Prim2 Gene Summary [Mouse]
Predicted to enable 4 iron, 4 sulfur cluster binding activity and DNA/RNA hybrid binding activity. Involved in DNA replication initiation and DNA replication, synthesis of primer. Part of alpha DNA polymerase:primase complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Orthologous to human PRIM2 (DNA primase subunit 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Prim2 |
| Official Name | DNA primase, p58 subunit [Source:MGI Symbol;Acc:MGI:97758] |
| Ensembl ID | ENSMUSG00000026134 |
| Bio databases IDs | |
| Aliases | DNA primase, p58 subunit |
| Synonyms | DNA primase, p58 subunit, DNA primase subunit 2, p58, Pola3, PRIM2A, Primase large subunit |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Prim2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- binding protein
- Archaeal/eukaryotic core primase: Large subunit, PriL
- DNA-directed RNA polymerase
- nucleic acid binding
- nucleotidyltransferase
- enzyme
- protein binding
Pathways
Biological processes and signaling networks where the Prim2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Huntington disease
- neoplasia
- precursor B-cell acute lymphoblastic leukemia
- organismal death
- chronic phase chronic myeloid leukemia
- myeloid sarcoma
- acute lymphoblastic lymphoma
- diffuse large B-cell lymphoma transformed from follicular lymphoma
- relapsed acute myeloid leukemia
- unclassifiable B-cell lymphoma
regulates
- RNA primer
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Prim2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA-dependent DNA replication initiation
- DNA replication, synthesis of RNA primer
Cellular Component
Where in the cell the gene product is active
- alpha DNA polymerase:primase complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding
- metal ion binding
- DNA/RNA hybrid binding
- 4 iron, 4 sulfur cluster binding