Atic Gene Summary [Mouse]
Enables IMP cyclohydrolase activity and phosphoribosylaminoimidazolecarboxamide formyltransferase activity. Involved in purine ribonucleoside monophosphate biosynthetic process. Acts upstream of or within cellular response to interleukin-7. Located in mitochondrion. Is expressed in several structures, including alimentary system; heart; nervous system; sensory organ; and urinary system. Human ortholog(s) of this gene implicated in purine-pyrimidine metabolic disorder. Orthologous to human ATIC (5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Atic |
| Official Name | 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase [Source:MGI Symbol;Acc:MGI:1351352] |
| Ensembl ID | ENSMUSG00000026192 |
| Bio databases IDs | |
| Aliases | 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase |
| Synonyms | 2610509C24Rik, 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase, AICAR, AICARFT, HEL-S-70p, IMPCHASE, LOC100910688, PURH |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Atic often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- MGS-like domain
- phosphoribosylaminoimidazolecarboxamide formyltransferase
- MGS-like
- phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase
- protein homodimerization
- IMP cyclohydrolase
- enzyme
- protein binding
- AICARFT/IMPCHase bienzyme
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- cancer
- lung squamous cell carcinoma
- metastatic non-squamous non-small cell lung cancer
- lung cancer
- advanced non-small cell lung cancer
- metastatic large cell lung carcinoma
- metastatic lung adenocarcinoma
- ATIC deficiency
- advanced large cell lung carcinoma
role in cell
- expression in
- proliferation
- growth
- colony formation
- transformation
- crizotinib sensitivity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Plasma Membrane
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Atic gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- 'de novo' AMP biosynthetic process
- cerebellum development
- dihydrofolate metabolic process
- brainstem development
- 'de novo' IMP biosynthetic process
- tetrahydrofolate biosynthetic process
- organ regeneration
- cerebral cortex development
- GMP biosynthetic process
- 'de novo' XMP biosynthetic process
- nucleobase-containing compound metabolic process
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- membrane
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein homodimerization activity
- cadherin binding
- IMP cyclohydrolase activity
- phosphoribosylaminoimidazolecarboxamide formyltransferase activity