Rab17 Gene Summary [Mouse]
Predicted to enable GDP binding activity and GTPase activity. Involved in several processes, including immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor; melanosome transport; and regulation of plasma membrane bounded cell projection organization. Located in several cellular components, including apical plasma membrane; basolateral plasma membrane; and cytoplasmic vesicle. Is active in glutamatergic synapse and postsynapse. Is expressed in several structures, including brain; gut; metanephros; olfactory epithelium; and salivary gland primordium. Orthologous to human RAB17 (RAB17, member RAS oncogene family). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rab17 |
| Official Name | RAB17, member RAS oncogene family [Source:MGI Symbol;Acc:MGI:104640] |
| Ensembl ID | ENSMUSG00000026304 |
| Bio databases IDs | |
| Aliases | RAB17, member RAS oncogene family |
| Synonyms | RAB17, member RAS oncogene family, RGD1562478 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rab17 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Small GTPase of the Ras superfamily (ill-defined subfamily)
- Ras family
- GTPase
- enzyme
- protein binding
- Ras subfamily of RAS small GTPases
- small GTP-binding protein domain
- GDP binding
- Rab subfamily of small GTPases
- Ras of Complex, Roc, domain of DAPkinase
- Rho (Ras homology) subfamily of Ras-like small GTPases
- Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases
- P-loop containing Nucleoside Triphosphate Hydrolases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- epithelial cancer
- liver cancer
- hepatitis B virus-related hepatocellular carcinoma
role in cell
- proliferation
- growth
- quantity
- degradation in
- formation
- assembly
- development
- endocytosis by
- branching
- development in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular nanovesicle
- glutaminergic synapse
- postsynaptic region
- Nucleus
- Plasma Membrane
- apical membrane
- basolateral membrane
- endosomal membrane
- dendritic spines
- growth cone
- recycling endosomes
- early endosomes
- endocytotic vesicle
- melanosomes
- perikaryon
- dendrites
- dendritic shafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rab17 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cilium morphogenesis
- endocytosis
- intracellular protein transport
- filopodium assembly
- regulation of dendrite development
- regulation of filopodium assembly
- immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor
- transcytosis
- regulation of endocytosis
- regulation of synapse assembly
- establishment of melanosome localization
- endocytic recycling
- melanosome transport
Cellular Component
Where in the cell the gene product is active
- neuronal cell body
- plasma membrane
- endocytic vesicle
- dendrite
- early endosome
- extracellular vesicular exosome
- melanosome
- endomembrane system
- recycling endosome
- recycling endosome membrane
- basolateral plasma membrane
- apical plasma membrane
Molecular Function
What the gene product does at the molecular level
- GTP binding
- protein binding
- GTPase activity
- GDP binding