Anpep Gene Summary [Mouse]
Enables metallopeptidase activity. Involved in angiotensin maturation. Is active in external side of plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; liver; and sensory organ. Orthologous to human ANPEP (alanyl aminopeptidase, membrane). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Anpep |
| Official Name | alanyl (membrane) aminopeptidase [Source:MGI Symbol;Acc:MGI:5000466] |
| Ensembl ID | ENSMUSG00000039062 |
| Bio databases IDs | |
| Aliases | alanyl (membrane) aminopeptidase |
| Synonyms | AAP, Ala-(Leu-Gly)-Aminopeptidase, Alanine Aminopeptidase, alanyl aminopeptidase, membrane, AMINOPEPTIDASE M, Aminopeptidase n, AP-M, AP-N, CD13, GP150, hAPN, Kidney Aminopeptidase M, KZP, LAP1, P150, PEPN, rAPN |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Anpep often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Peptidase M1 N-terminal domain
- metallopeptidase
- peptide binding
- Peptidase family M1 domain
- signaling receptor activity
- ERAP1-like C-terminal domain
- membrane alanyl aminopeptidase
- peptidase
- aminopeptidase
- peptidase GluZincin family
Pathways
Biological processes and signaling networks where the Anpep gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- renal cell cancer
- epithelial cancer
- invasive breast cancer
- metastatic myxoid liposarcoma
- acute myeloid leukemia
- metastatic leiomyosarcoma
- metastatic pleomorphic liposarcoma
- COVID-19
- leiomyosarcoma
role in cell
- expression in
- apoptosis
- production in
- differentiation
- number
- activation in
- proliferation
- function
- migration
- formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- tetraspanin-enriched microdomain
- Cytoplasm
- cell surface
- Extracellular Space
- intracellular space
- cellular membrane
- Golgi Apparatus
- Endoplasmic Reticulum
- secretory granule membrane
- ER-to-Golgi intermediate compartment
- plasma membrane extracellular face
- apical membrane
- brush border
- Golgi vesicles
- exosomes
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Anpep gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- viral entry into host cell
- peptide catabolic process
- angiogenesis
- proteolysis
- cell differentiation
Cellular Component
Where in the cell the gene product is active
- secretory granule membrane
- extracellular space
- extracellular vesicular exosome
- cytoplasm
- external side of plasma membrane
- endoplasmic reticulum-Golgi intermediate compartment
- lysosomal membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- signaling receptor activity
- metalloaminopeptidase activity
- aminopeptidase activity
- viral receptor activity
- peptide binding
- metallopeptidase activity