Nfia Gene Summary [Mouse]
Enables DNA binding activity and chromatin binding activity. Involved in several processes, including BMP signaling pathway; limb morphogenesis; and positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including exit from mitosis; nervous system development; and ureter development. Located in nucleus. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in NFIA-related disorder. Orthologous to human NFIA (nuclear factor I A). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nfia |
| Official Name | nuclear factor I/A [Source:MGI Symbol;Acc:MGI:108056] |
| Ensembl ID | ENSMUSG00000028565 |
| Bio databases IDs | |
| Aliases | nuclear factor I/A |
| Synonyms | 1110047K16Rik, 9430022M17RIK, BRMUTD, C1DELp32p31, CTF, DEL1P32P31, NF1-A, Nf1-A1, NF-I/A, NFI-L, Nuclear factor 1/A, nuclear factor I A, nuclear factor I/A, Rpbf1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Nfia often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- transcription regulator
- dimerization domain
- DNA binding domain
- nucleic acid binding
- transcription factor binding
- chromatin binding
- protein binding
- sequence-specific DNA binding
- zDHHC ankyrin repeat binding domain
- N-terminal Mad Homology 1 (MH1) domain
- DNA binding
- Nuclear factor I protein pre-N-terminus
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- double-stranded DNA binding
- MH1 domain
- CTF/NF-I family transcription modulation region
Pathways
Biological processes and signaling networks where the Nfia gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- tumorigenesis
- alcoholism
- bipolar disorder
- double ureter
- chromosome 1p32-p31 deletion syndrome
- self-abusive behavior
- myopia
- tremor
- epithelial thyroid cancer
- renal duplication
role in cell
- apoptosis
- expression in
- proliferation
- formation
- differentiation
- accumulation in
- maturation
- quantity
- transactivation in
- migration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- cell junction
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Nfia gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- synapse maturation
- retina development in camera-type eye
- cell morphogenesis
- neural precursor cell proliferation
- DNA replication
- response to wounding
- regulation of transcription, DNA-dependent
- positive regulation of transcription from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
- glial cell fate specification
- neuron fate specification
- BMP signaling pathway
- ureter development
- gene expression
- viral genome replication
- limb morphogenesis
- exit from mitosis
- glial cell proliferation
- cartilage development
Cellular Component
Where in the cell the gene product is active
- nucleus
- cell junction
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- sequence-specific DNA binding transcription factor activity
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- chromatin binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity