Lamb1 Gene Summary [Mouse]
Enables enzyme binding activity; glycosphingolipid binding activity; and integrin binding activity. Involved in negative regulation of cell adhesion. Acts upstream of or within cell migration; embryo implantation; and neuron projection development. Located in basement membrane; nucleus; and perinuclear region of cytoplasm. Part of laminin-1 complex and laminin-10 complex. Is expressed in several structures, including alimentary system; central nervous system; extraembryonic component; eye; and genitourinary system. Human ortholog(s) of this gene implicated in autistic disorder and lissencephaly 5. Orthologous to human LAMB1 (laminin subunit beta 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Lamb1 |
| Official Name | laminin B1 [Source:MGI Symbol;Acc:MGI:96743] |
| Ensembl ID | ENSMUSG00000002900 |
| Bio databases IDs | |
| Aliases | laminin B1 |
| Synonyms | C80098, CLM, D130003D08Rik, LAMB1-1, Lamb1-1 predicted, Laminin b1, LAMININ beta 1, laminin subunit beta 1, laminin subunit β 1, LAMININ β 1, LIS5 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Lamb1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Glutamic acid/alanine-rich protein of Trypanosoma
- Vps5 C terminal like
- F-type ATP synthase, membrane subunit b
- helix-rich Mycoplasma protein
- Bin/Amphiphysin/Rvs domain
- laminin receptor binding domain
- ATP synthase B/B' CF(0)
- Laminin Domain I
- EGF_CA
- Laminin-type epidermal growth factor-like domai
- Tropomyosin
- Mitochondrial ATP synthase subunit
- Family with sequence similarity 184, A and B
- BRE1 E3 ubiquitin ligase
- C-terminal coiled-coil domain found in the laminin subunit beta (LAMB) family
- Apolipophorin-III precursor (apoLp-III)
- Mitotic checkpoint protein
- DivIVA protein
- Laminin N-terminal (Domain VI)
- Rabaptin-like protein
- sphingolipid binding
- TPR/MLP1/MLP2-like protein
- RNase Y N-terminal region
- lipid binding
- Tropomyosin like
- PspA/IM30 family
- Ezrin/radixin/moesin, alpha-helical domain
- Hyaluronan mediated motility receptor N-terminal
- enzyme binding
- extracellular matrix structural constituent
- protein binding
- PLC-beta C terminal
- Mechanosensitive ion channel porin domain
- binding protein
- Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer)
- prefoldin
- Methyl-accepting chemotaxis protein (MCP), signaling domain
- Trichohyalin-plectin-homology domain
- integrin binding
- Apolipoprotein A1/A4/E domain
- Laminin EGF domain
Pathways
Biological processes and signaling networks where the Lamb1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- liver cancer
- epithelial cancer
- head and neck neoplasia
- neoplasia
- Huntington disease
- inflammatory bowel disease
- plexiform neurofibroma
- cobblestone lissencephaly without muscular or ocular involvement
- chronic obstructive pulmonary disease
- lissencephaly type 5
role in cell
- migration
- expression in
- proliferation
- growth
- development
- organization
- effacement
- transmigration
- adhesion
- morphogenesis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- extracellular vesicles
- cell surface
- perinuclear region
- Nucleus
- endoplasmic reticulum lumen
- extracellular matrix
- basal lamina
- plasma
- basement membrane
- endothelial basement membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Lamb1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neuronal-glial interaction involved in cerebral cortex radial glia guided migration
- neuron projection development
- substrate adhesion-dependent cell spreading
- endodermal cell differentiation
- cell adhesion
- positive regulation of cell adhesion
- odontogenesis
- positive regulation of epithelial cell proliferation
- positive regulation of integrin-mediated signaling pathway
- positive regulation of muscle cell differentiation
- positive regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum lumen
- extracellular space
- basement membrane
- perinuclear region of cytoplasm
- extracellular vesicular exosome
- laminin-1 complex
- laminin-2 complex
- laminin-8 complex
- laminin-10 complex
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding
- structural molecule activity
- extracellular matrix structural constituent