Slc25a25 Gene Summary [Mouse]
Predicted to enable ATP:phosphate antiporter activity. Acts upstream of or within several processes, including response to activity; response to dietary excess; and response to food. Located in mitochondrion. Is expressed in several structures, including alimentary system; eye; genitourinary system; hemolymphoid system gland; and nervous system. Orthologous to human SLC25A25 (solute carrier family 25 member 25). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Slc25a25 |
| Official Name | solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 25 [Source:MGI Symbol;Acc:MGI:1915913] |
| Ensembl ID | ENSMUSG00000026819 |
| Bio databases IDs | |
| Aliases | solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 25 |
| Synonyms | 1110030N17Rik, MCSC, mKIAA1896, PCSCL, SCAMC-2, solute carrier family 25 member 25, solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 25 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Slc25a25 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ATP transporter
- EF-hand domain
- EF-hand domain pair
- EF hand
- EF-hand, calcium binding motif, found in parvalbumin-like EF-hand family
- Mitochondrial carrier protein
- EFh
- transporter
- organophosphate:inorganic phosphate antiporter
- EFh_PI-PLC
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- weight gain
- obesity
- cataract disease
- epileptic seizure
regulates
- Ca2+
- D-glucose
- adenosine triphosphate
- oxygen
role in cell
- production in
- respiration
- flux in
- function
- mitochondrial respiration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- myelin enriched fraction
- Mitochondria
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Slc25a25 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to food
- multicellular organism growth
- camera-type eye development
- ATP metabolic process
- calcium ion transmembrane transport
- cellular respiration
- response to activity
- response to dietary excess
- ATP transport
- ADP transport
- adipose tissue development
Cellular Component
Where in the cell the gene product is active
- mitochondrion
- mitochondrial inner membrane
Molecular Function
What the gene product does at the molecular level
- calcium ion binding
- ATP transmembrane transporter activity